Trial reportGynecologic oncology2012
Randomized comparison of near-infrared fluorescence lymphatic tracers for sentinel lymph node mapping of cervical cancer.
Trial report in Gynecologic oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02690259 (Near Infrared Fluorescent Technique for Sentinel Lymph Node Mapping in Endometrial Cancer), which is not on this map. Cited by 38 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Near Infrared Fluorescent Technique for Sentinel Lymph Node Mapping in Endometrial Cancer
Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Sentinel node navigation surgery in cervical cancer: a systematic review and metaanalysis.International journal of clinical oncology · 2022Pooled it
- Indocyanine green versus technetium-99m with blue dye for sentinel lymph node detection in early-stage cervical cancer: A systematic review and meta-analysis.Cancer reports (Hoboken, N.J.) · 2022Pooled it
- Utility of Intraoperative Fluorescence Imaging in Gynecologic Surgery: Systematic Review and Consensus Statement.Annals of surgical oncology · 2021Pooled it
- Indocyanine green can stand alone in detecting sentinel lymph nodes in cervical cancer.The Journal of international medical research · 2018Pooled it
- Sentinel-lymph-node procedures in early stage cervical cancer: a systematic review and meta-analysis.Medical oncology (Northwood, London, England) · 2015Pooled it
- Safety and feasibility of near-infrared image-guided lymphatic mapping of regional lymph nodes in esophageal cancer.The Journal of thoracic and cardiovascular surgery · 2016Trial
- Evaluation of a radioactive and fluorescent hybrid tracer for sentinel lymph node biopsy in head and neck malignancies: prospective randomized clinical trial to compare ICG-(99m)Tc-nanocolloid hybrid tracer versus (99m)Tc-nanocolloid.European journal of nuclear medicine and molecular imaging · 2015Trial
- Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers.BJOG : an international journal of obstetrics and gynaecology · 2013Trial
- Review of Clinically Assessed Molecular Fluorophores for Intraoperative Image Guided Surgery.Molecules (Basel, Switzerland) · 2024Review
- Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine Green.Sensors (Basel, Switzerland) · 2023Article
- Indocyanine Green-based Glow Nanoparticles Probe for Cancer Imaging.Nanotheranostics · 2023Article
- Article
- Detection of the sentinel lymph node with hybrid tracer (ICG-[EJNMMI research · 2021Article
- Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique.Journal of clinical medicine · 2021Article
- Sentinel lymph node mapping with indocyanine green in cervical cancer patients undergoing open radical hysterectomy: a single-institution series.Journal of cancer research and clinical oncology · 2021Observational
- Indocyanine Green Loaded Polymeric Nanoparticles: Physicochemical Characterization and Interaction Studies with Caco-2 Cell Line by Light and Transmission Electron Microscopy.Nanomaterials (Basel, Switzerland) · 2020Article
- Small Molecules for Multi-Wavelength Near-Infrared Fluorescent Mapping of Regional and Sentinel Lymph Nodes in Colorectal Cancer Staging.Frontiers in oncology · 2020Article
- S122: impact of fluorescence and 3D images to completeness of lateral pelvic node dissection.Surgical endoscopy · 2020Article
- A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery.Journal of surgical oncology · 2018Review
- Sentinel lymph node mapping in gynecological oncology.Oncology letters · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveNear-infrared fluorescence imaging using indocyanine green (ICG) has recently been introduced as a novel technique for sentinel lymph node (SLN) mapping in early-stage cervical cancer. Although preclinical research has shown that ICG adsorbed to human serum albumin (ICG:HSA) improves its performance, the need for HSA has not yet been confirmed in cervical cancer patients. The current randomized study aims to determine whether ICG:HSA offers advantages over using ICG alone.
methodsEighteen consecutive early-stage cervical cancer patients scheduled to undergo pelvic lymphadenectomy were included. Prior to surgery, 1.6 mL of 500 μM ICG:HSA or 500 μM ICG alone was injected transvaginally in 4 quadrants around the tumor. The Mini-FLARE imaging system was used for intraoperative NIR fluorescence detection and quantitation.
resultsSLNs were identified intraoperatively in 78% of the patients. Patient and tumor characteristics were equally distributed over both treatment groups. No significant difference in signal-to-background ratio (9.3 vs. 10.1, P=.72) or average number of detected SLNs (2.9 vs 2.7, P=.84) was found between the ICG:HSA group and the ICG alone group, respectively.
conclusionsIn conclusion, this double-blind, randomized trial showed no advantage of ICG:HSA over ICG alone for the SLN procedure in early-stage cervical cancer. Further optimization is required to improve the intraoperative detection rate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.