ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Role of matrix Gla protein in angiotensin II-induced exacerbation of vascular calcification.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis.The American journal of clinical nutrition · 2013Trial
- Single-Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cell-Free bone regeneration using dental MSCs secretomes from pulp and gingiva in rabbit tibial defects.Scientific reports · 2025Article
- Involvement of miRNA-204 carried by the exosomes of macrophages in the AT2 receptor-mediated improvement of vascular calcification.Cellular and molecular life sciences : CMLS · 2025Article
- Myocardial fibrosis and calcification are attenuated by microRNA-129-5p targeting Asporin and Sox9 in cardiac fibroblasts.JCI insight · 2023Article
- A Low Concentration of Citreoviridin Prevents Both Intracellular Calcium Deposition in Vascular Smooth Muscle Cell and Osteoclast Activation In Vitro.Molecules (Basel, Switzerland) · 2023Article
- Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease.Renal failure · 2021Article
- Vitamin K intake and health, consideration from the epidemiological studies.Journal of clinical biochemistry and nutrition · 2021Article
- The protective effects of renin-angiotensin system componts on vascular calcification.Journal of human hypertension · 2021Article
- Circadian rhythm disorder: a potential inducer of vascular calcification?Journal of physiology and biochemistry · 2020Review
- Involvement of angiotensin II receptor type 1/NF-κB signaling in the development of endometriosis.Experimental and therapeutic medicine · 2020Article
- Cortistatin exerts antiproliferation and antimigration effects in vascular smooth muscle cells stimulated by Ang II through suppressing ERK1/2, p38 MAPK, JNK and ERK5 signaling pathways.Annals of translational medicine · 2019Article
- The Role of Vitamin K and Its Related Compounds in Mendelian and Acquired Ectopic Mineralization Disorders.International journal of molecular sciences · 2019Review
- JAK2/STAT3/BMP-2 axis and NF-κB pathway are involved in erythropoietin-induced calcification in rat vascular smooth muscle cells.Clinical and experimental nephrology · 2019Article
- Methylation and expression of RECK, P53 and RUNX genes in patients with esophageal cancer.Oncology letters · 2017Article
- Circulating Vitamin K Is Inversely Associated with Incident Cardiovascular Disease Risk among Those Treated for Hypertension in the Health, Aging, and Body Composition Study (Health ABC).The Journal of nutrition · 2017Article
- Apocynin attenuates angiotensin II-induced vascular smooth muscle cells osteogenic switching via suppressing extracellular signal-regulated kinase 1/2.Oncotarget · 2016Article
- Vascular calcification is coupled with phenotypic conversion of vascular smooth muscle cells through Klf5-mediated transactivation of the Runx2 promoter.Bioscience reports · 2014Article
- Angiotensin II and vascular injury.Current hypertension reports · 2014Review
- Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein.Cardiovascular diabetology · 2014Article
Corrections and comments
- Erratum issuedCorrigendum.2016
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Vascular calcification predicts an increased risk for cardiovascular events in atherosclerosis, diabetes, and end-stage kidney diseases. Matrix Gla protein (MGP), an inhibitor of calcification, limits calcium phosphate deposition in the vessel wall. There are many factors contributing to the progression of atherosclerosis, including hypertension, hyperlipidemia, the renin-angiotensin system, and inflammation. Angiotensin II (ANG II) plays a crucial role in the atherogenic process through not only its pressor responses but also its growth-promoting and inflammatory effects. In this study, we investigated the role of MGP in ANG II-induced exacerbation of vascular calcification in human vascular smooth muscle cells (VSMCs). The expression of MGP, calcification, and apoptosis in human VSMCs were examined by Western blot analysis, real-time PCR, in situ terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling, and enzyme-linked immunosorbent assay, respectively. Increase in VSMC calcification in human atherosclerotic plaques upregulates MGP expression and apoptosis in a negative feedback manner. ANG II inhibited MGP expression in VSMCs via and in vitro in a dose- and time-dependent manner through ANG II type 1 receptor and NF-κB signaling pathway. Meanwhile, MGP inhibited the calcification, caspase-3 activity, activation of runt-related transcription factor 2, and release of inflammatory cytokines by VSMCs induced by calcification medium (2.5 mM P(i)) and ANG II in vitro. These observations provide evidence that ANG II exacerbates vascular calcification through activation of the transcription factors, runt-related transcription factor 2 and NF-κB, and regulation of MGP, inflammatory cytokines expression in human VSMCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.