ArticleJournal of theoretical biology2012
The contribution of age structure to cell population responses to targeted therapeutics.
Article in Journal of theoretical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Age-structured mechanical models for tumor growth.Journal of mathematical biology · 2026Article
- Cell Population Dynamics Informed by Cell-Cycle Regulation: A Deterministic Modeling Toolkit.Computational and structural biotechnology journal · 2026Review
- Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation.Aging and disease · 2025Review
- Characterising the Behaviour of a Structured PDE Model of the Cell Cycle in Contrast to a Corresponding ODE System.Bulletin of mathematical biology · 2025Article
- Stability analysis of a multiscale model of cell cycle dynamics coupled with quiescent and proliferating cell populations.PloS one · 2023Article
- A framework for macroscopic phase-resetting curves for generalised spiking neural networks.PLoS computational biology · 2022Article
- A novel mathematical model of heterogeneous cell proliferation.Journal of mathematical biology · 2021Article
- Article
- A computational model of feedback-mediated hematopoietic stem cell differentiation in vitro.PloS one · 2019Article
- A drift-diffusion checkpoint model predicts a highly variable and growth-factor-sensitive portion of the cell cycle G1 phase.PloS one · 2018Article
- Structured models of cell migration incorporating molecular binding processes.Journal of mathematical biology · 2017Article
- Stochastic multi-scale models of competition within heterogeneous cellular populations: Simulation methods and mean-field analysis.Journal of theoretical biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to minimize the variation in cell cycle position. However, synchronization techniques are cumbersome and imprecise and the agents used to synchronize the cells potentially have other unknown effects on the cells. An alternative approach is to determine the age structure in the population and account for the cell cycle positional effects post hoc. Here we provide a formalism to use quantifiable lifespans from live cell microscopy experiments to parameterize an age-structured model of cell population response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.