ArticleContemporary clinical trials2012
Improving the efficiency and effectiveness of pragmatic clinical trials in older adults in the United States.
Article in Contemporary clinical trials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Individualized patient decision-aid for immunosuppressive drugs in women with lupus nephritis: study protocol of a randomized, controlled trial.BMC musculoskeletal disorders · 2017Trial
- Conduction of Pragmatic Clinical Trials in Routine Clinical Settings: Guidelines for Development of Protocol.Current therapeutic research, clinical and experimental · 2026Review
- A Centralized Survey Model for Clinician Engagement in Practice-Based Research Networks (PBRNs).Journal of the American Board of Family Medicine : JABFM · 2026Article
- Real-world data analysis of bilayered living cellular construct and fetal bovine collagen dressing treatment for pressure injuries: a comparative effectiveness study.Journal of comparative effectiveness research · 2024Article
- Article
- Digital Informed Consent for Older Adults in Emergency Department Research.Applied Human Factors and Ergonomics Conference · 2023Article
- Efficacy of affirmative cognitive behavioural group therapy for sexual and gender minority adolescents and young adults in community settings in Ontario, Canada.BMC psychology · 2021Article
- Treatment decisions in multiple sclerosis - insights from real-world observational studies.Nature reviews. Neurology · 2017Review
- Prognostic and Therapeutic Implications of Frailty in Older Adults with Heart Failure.Current cardiology reports · 2015Review
- Clinical Comparative Effectiveness Research Through the Lens of Healthcare Decisionmakers.Ochsner journal · 2015Review
- Use of health plan combined with registry data to predict clinical trial recruitment.Clinical trials (London, England) · 2014Article
- The role of pragmatic clinical trials in the evolution of learning health systems.Transactions of the American Clinical and Climatological Association · 2014Review
- New methods for determining comparative effectiveness in rheumatoid arthritis.Current opinion in rheumatology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
Abstract
Pragmatic clinical trials (PCTs) seek to improve the generalizability and increase the statistical power of traditional explanatory trials. They are a major tenet of comparative effectiveness research. While a powerful study design, PCTs have been limited by high cost, modest efficiency, and limited ability to fill relevant evidence gaps. Based on an American Reinvestment and Recovery Act (ARRA) supported meeting of national stakeholders, we propose several innovations and future research that could improve the efficiency and effectiveness of such studies focused in the U.S. Innovations discussed include optimizing the use of community based practices through partnership with Practice Based Research Networks (PBRNs), using information technology to simplify PCT subject recruitment, consent and randomization processes, and utilizing linkages to large administrative databases, such as Medicare, as a mechanism to capture outcomes and other important PCT variables with lower subject and research team burden. Testing and adaptation of such innovations to PCT are anticipated to improve the public health value of these increasingly important studies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.