Evidence map›Paper›PMID 22796039›Full record

ReviewClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2012

Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions.

Craig E Tenke, Jürgen Kayser

Abstract readReview
In one paragraph

Review in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 282 citations in OpenAlex.

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  6. Preparatory Attention to Visual Features Spreads Globally.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  11. Hierarchical Organization of Human Visual Feature Attention Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  20. Breakthroughs and challenges for generating brain network-based biomarkers of treatment response in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Craig E TenkeDivision of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA. tenkecr@nyspi.columbia.edu
Jürgen Kayser
New York Psychoanalytic Society and Institute · USNew York State Psychiatric Institute

Funding

Three Generations at High and Low Risk for Depression Followed LongitudinallyR01MH036197 · NIMH · YALE UNIVERSITY · PI POSNER, JONATHAN E, WEISSMAN, MYRNA M · 1985 to 2020
$15.0M
Biosignatures of Treatment Remission in Major DepressionU01MH092250 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MCGRATH, PATRICK J, PARSEY, RAMIN V. · 2010 to 2015
$8.9M
BEHAVIORAL, ERP AND RCBF ASYMMETRY IN AFFECTIVE DISORDERR01MH036295 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BRUDER, GERARD E · 1985 to 2012
$3.7M
Subtypes of Schizophrenia: ERPs During Memory ProcessingR01MH066597 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BRUDER, GERARD E · 2004 to 2008
$1.8M
Olfaction and Emotion in Depression: Behavioral Electrodermal and ERP MeasuresR21MH082393 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KAYSER, RALF JÜRGEN · 2008 to 2009
$396k
Time-Frequency Measures for Predicting Response to AntidepressantsR03MH094356 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BRUDER, GERARD E, TENKE, CRAIG E · 2011 to 2012
$160k
ELECTROPHYSIOLOGY STUDIES OF PSYCHOMOTOR PROCESSESR01MH006723 · NIMH · YESHIVA UNIVERSITY · PI AREZZO, JOSEPH C · 1985 to 1994
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NIMH NIH HHS MH06723NIMH NIH HHS MH082393NIMH NIH HHS MH094356NIMH NIH HHS MH36295NIMH NIH HHS MH66597NIMH NIH HHS R01 MH036197NIMH NIH HHS R01 MH036295NIMH NIH HHS R01 MH066597NIMH NIH HHS R03 MH094356NIMH NIH HHS R21 MH082393NIMH NIH HHS U01 MH092250
6 · The paper itself

Abstract

The topographic ambiguity and reference-dependency that has plagued EEG/ERP research throughout its history are largely attributable to volume conduction, which may be concisely described by a vector form of Ohm's Law. This biophysical relationship is common to popular algorithms that infer neuronal generators via inverse solutions. It may be further simplified as Poisson's source equation, which identifies underlying current generators from estimates of the second spatial derivative of the field potential (Laplacian transformation). Intracranial current source density (CSD) studies have dissected the "cortical dipole" into intracortical sources and sinks, corresponding to physiologically-meaningful patterns of neuronal activity at a sublaminar resolution, much of which is locally cancelled (i.e., closed field). By virtue of the macroscopic scale of the scalp-recorded EEG, a surface Laplacian reflects the radial projections of these underlying currents, representing a unique, unambiguous measure of neuronal activity at scalp. Although the surface Laplacian requires minimal assumptions compared to complex, model-sensitive inverses, the resulting waveform topographies faithfully summarize and simplify essential constraints that must be placed on putative generators of a scalp potential topography, even if they arise from deep or partially-closed fields. CSD methods thereby provide a global empirical and biophysical context for generator localization, spanning scales from intracortical to scalp recordings.

Indexed as

AlgorithmsBrainBrain MappingElectroencephalographyEvoked PotentialsHumansNeural ConductionScalp

Identifiers

PMID22796039
PMCPMC3498576
OpenAlexW2151091968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.