ArticleBiological psychiatry2013
Age-specific effects of voluntary exercise on memory and the older brain.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Effect of exercise on cognitive function in chronic disease patients: a meta-analysis and systematic review of randomized controlled trials.Clinical interventions in aging · 2017Pooled it
- A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor.Journal of psychiatric research · 2015Pooled it
- Exerkine irisin mitigates cognitive impairment by suppressing gut-brain axis-mediated inflammation.Journal of advanced research · 2025Article
- TAF15 downregulation contributes to the benefits of physical training on dendritic spines and working memory in aged mice.Aging cell · 2024Article
- Environmental enrichment in middle age rats improves spatial and object memory discrimination deficits.Frontiers in behavioral neuroscience · 2024Article
- Physical Exercise as an Intervention for Depression: Evidence for Efficacy and Mu-Opioid Receptors as a Mechanism of Action.Advances in neurobiology · 2024Review
- Effects of acute aerobic exercise on mnemonic discrimination performance in older adults.Journal of the International Neuropsychological Society : JINS · 2023Article
- Review
- Temporal endurance of exercise-induced benefits on hippocampus-dependent memory and synaptic plasticity in female mice.Neurobiology of learning and memory · 2022Article
- The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice.Aging and disease · 2022Article
- Autologous skin-derived neural precursor cell therapy reverses canine Alzheimer dementia-like syndrome in a proof of concept veterinary trial.Stem cell research & therapy · 2022Article
- Comparative efficacy of non-pharmacological interventions on behavioural and psychological symptoms in elders with dementia: A network meta-analysis.Nursing open · 2021Review
- Regular physical activity postpones age of occurrence of first-ever stroke and improves long-term outcomes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechin in Aged Rats.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- The Mechanism of Physical Activity-induced Amelioration of Parkinson's Disease: A Narrative Review.Aging and disease · 2021Review
- Transcriptome Analysis in a Mouse Model of Premature Aging of Dentate Gyrus: Rescue of Alpha-Synuclein Deficit by Virus-Driven Expression or by Running Restores the Defective Neurogenesis.Frontiers in cell and developmental biology · 2021Article
- Learning-Dependent Dendritic Spine Plasticity Is Reduced in the Aged Mouse Cortex.Frontiers in neural circuits · 2020Article
- Interaction Between Neurogenic Stimuli and the Gene Network Controlling the Activation of Stem Cells of the Adult Neurogenic Niches, in Physiological and Pathological Conditions.Frontiers in cell and developmental biology · 2020Review
- Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI.Frontiers in physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPhysical exercise in early adulthood and mid-life improves cognitive function and enhances brain plasticity, but the effects of commencing exercise in late adulthood are not well-understood.
methodWe investigated the effects of voluntary exercise in the restoration of place recognition memory in aged rats and examined hippocampal changes of synaptic density and neurogenesis.
resultsWe found a highly selective age-related deficit in place recognition memory that is stable across retest sessions and correlates strongly with loss of hippocampal synapses. Additionally, 12 weeks of voluntary running at 20 months of age removed the deficit in the hippocampally dependent place recognition memory. Voluntary running restored presynaptic density in the dentate gyrus and CA3 hippocampal subregions in aged rats to levels beyond those observed in younger animals, in which exercise had no functional or synaptic effects. By contrast, hippocampal neurogenesis, a possible memory-related mechanism, increased in both young and aged rats after physical exercise but was not linked with performance in the place recognition task. We used graph-based network analysis based on synaptic covariance patterns to characterize efficient intrahippocampal connectivity. This analysis revealed that voluntary running completely reverses the profound degradation of hippocampal network efficiency that accompanies sedentary aging. Furthermore, at an individual animal level, both overall hippocampal presynaptic density and subregional connectivity independently contribute to prediction of successful place recognition memory performance.
conclusionsOur findings emphasize the unique synaptic effects of exercise on the aged brain and their specific relevance to a hippocampally based memory system for place recognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.