Evidence map›Paper›PMID 22795930›Full record

ReviewMagnetic resonance imaging2012

Simultaneous PET-MRI in oncology: a solution looking for a problem?

Thomas E Yankeelov, Todd E Peterson, Richard G Abramson, David Izquierdo-Garcia, David Garcia-Izquierdo, Lori R Arlinghaus, Xia Li, Nkiruka C Atuegwu, Ciprian Catana, H Charles Manning and 2 more

Erratum issuedAbstract readReview
In one paragraph

Review in Magnetic resonance imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
  2. Theranostics in nuclear medicine: the era of precision oncology.Medical oncology (Northwood, London, England) · 2025
    Review
  3. Review
  4. Article
  5. Medical Imaging Technology and Imaging Agents.Advances in experimental medicine and biology · 2023
    Article
  6. Review
  7. Review
  8. Dynamic whole-body PET imaging: principles, potentials and applications.European journal of nuclear medicine and molecular imaging · 2019
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Current Status of Hybrid PET/MRI in Oncologic Imaging.AJR. American journal of roentgenology · 2016
    Review
  18. Hybrid MR-PET in Neuroimaging.Clinical neuroradiology · 2015
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
    Garcia-Izquierdo, David [corrected to Izquierdo-Garcia, David]
5 · Who and what money

Authors and funding

12 authors.

Thomas E YankeelovInstitute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA. thomas.yankeelov@vanderbilt.edu
Todd E Peterson
Richard G Abramson
David Izquierdo-Garcia
David Garcia-Izquierdo
Lori R Arlinghaus
Xia Li
Nkiruka C Atuegwu
Ciprian Catana
H Charles Manning
Zahi A Fayad
John C Gore

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
TISSUE CoreP50CA098131 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO, PIETENPOL, JENNIFER A · 2003 to 2024
$48.7M
MR/PET Imaging of coronary atherosclerosisR01HL071021 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2002 to 2019
$7.8M
Vanderbilt In Vivo Cellular and Molecular Imaging CenterP50CA128323 · NCI · VANDERBILT UNIVERSITY · PI SHYR, YU · 2008 to 2012
$6.8M
Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5M
MRI Diffusion in Tumors Using Oscillating GradientsR01CA109106 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI XU, JUNZHONG · 2006 to 2022
$4.0M
Quantitative MRI of Glioblastoma ResponseU01CA154601 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE · 2011 to 2016
$3.4M
Nanoparticles for Molecular MRI of AtherosclerosisR01HL078667 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2004 to 2008
$2.5M
Quantitative MR-PET for Therapy Assessment in Glioma PatientsR01CA137254 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CATANA, CIPRIAN, SCHMAND, MATTHIAS · 2009 to 2012
$2.5M
Evaluation and Validation of Imaging Biomarkers of Tumor Response to TreatmentR01CA138599 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MCINTYRE, JAMES OLIVER · 2010 to 2015
$2.2M
Biological Basis of Imaging Biomarkers in Colorectal CancerR01CA140628 · NCI · VANDERBILT UNIVERSITY · PI MANNING, HENRY CHARLES · 2009 to 2013
$1.5M
Comprehensive Evaluation of OGSE DWI for Assessing Tumor Treatment ResponseR01CA173593 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2013 to 2017
$1.3M
NCI NIH HHS 1P50 CA098131NCI NIH HHS 1 R01 CA137254-01A1NCI NIH HHS 1R01 CA140628NCI NIH HHS 1RC1 CA145138NCI NIH HHS K25 CA127349NCI NIH HHS K25 CA168936NCI NIH HHS P30 CA068485NCI NIH HHS P30 CA68485NCI NIH HHS P50 CA098131NCI NIH HHS P50 CA128323NCI NIH HHS R01 CA109106NCI NIH HHS R01 CA137254NCI NIH HHS R01 CA138599NCI NIH HHS R01CA138599NCI NIH HHS R01 CA140628NCI NIH HHS R01 CA173593NCI NIH HHS RC1 CA145138NCI NIH HHS U01 CA142565NCI NIH HHS U01 CA154601NCI NIH HHS U01CA154601-01NHLBI NIH HHS R01 HL071021NHLBI NIH HHS R01 HL078667
6 · The paper itself

Abstract

With the recent development of integrated positron emission tomography-magnetic resonance imaging (PET-MRI) scanners, new possibilities for quantitative molecular imaging of cancer are realized. However, the practical advantages and potential clinical benefits of the ability to record PET and MRI data simultaneously must be balanced against the substantial costs and other requirements of such devices. In this review, we highlight several of the key areas where integrated PET-MRI measurements, obtained simultaneously, are anticipated to have a significant impact on clinical and/or research studies. These areas include the use of MR-based motion corrections and/or a priori anatomical information for improved reconstruction of PET data, improved arterial input function characterization for PET kinetic modeling, the use of dual-modality contrast agents, and patient comfort and practical convenience. For widespread acceptance, a compelling case could be made if the combination of quantitative MRI and specific PET biomarkers significantly improves our ability to assess tumor status and response to therapy, and some likely candidates are now emerging. We consider the relative advantages and disadvantages afforded by PET-MRI and summarize current opinions and evidence as to the likely value of PET-MRI in the management of cancer.

Indexed as

Breast NeoplasmsContrast MediaDiagnostic ImagingFemaleHumansImage Processing, Computer-AssistedKineticsMagnetic Resonance ImagingMaleMedical OncologyMotionNeoplasmsPositron-Emission TomographyProstatic NeoplasmsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedContrast Media

Identifiers

PMID22795930
PMCPMC3466373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.