ArticleCurrent biology : CB2012
The evolutionary imprint of domestication on genome variation and function of the filamentous fungus Aspergillus oryzae.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
102 citing papers in PubMed, 215 citations in OpenAlex.
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- From Probiotics to Postbiotics-An Update on Their Biotherapeutic Potential and the Emerging Strategies in Human Health.International journal of molecular sciences · 2026Review
- Transdermal entry of a non-pathogenic filamentous fungusFrontiers in immunology · 2026Article
- Population-specific transcriptomic shifts underlie secondary metabolic diversification inIMA fungus · 2026Article
- Advancing solid-state fermentation with culinary fungi for nutrient-dense, minimally processed, whole-foods and resilient food systems-a narrative review.Frontiers in nutrition · 2026Review
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- Elevated rates and biased spectra of mutations in anaerobically cultured lactic acid bacteria.mBio · 2025Article
- Population-Specific Transcriptomic Shifts Underlie Secondary Metabolic Diversification inbioRxiv : the preprint server for biology · 2025Article
- Analysis of Amino Acid and Derivative Diversity and Antioxidant Capacity inJournal of fungi (Basel, Switzerland) · 2025Article
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- Harboring Starships: The Accumulation of Large Horizontal Gene Transfers in Domesticated and Pathogenic Fungi.Genome biology and evolution · 2025Article
- Genome diversity, population structure and MALDI-TOF MS profiling of Aspergillus oryzae/flavus strains from fermentation and wild environments.BMC genomics · 2025Article
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- Population Genomics of Aspergillus sojae is Shaped by the Food Environment.Genome biology and evolution · 2025Article
- Species Identification and Orthologous Allergen Prediction and Expression in the GenusJournal of fungi (Basel, Switzerland) · 2025Article
- Fungi as Food.Current topics in microbiology and immunology · 2025Review
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- Divergent volatile metabolomes and flavor attributes in rice fermented byFrontiers in fungal biology · 2025Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The domestication of animals, plants, and microbes fundamentally transformed the lifestyle and demography of the human species [1]. Although the genetic and functional underpinnings of animal and plant domestication are well understood, little is known about microbe domestication [2-6]. Here, we systematically examined genome-wide sequence and functional variation between the domesticated fungus Aspergillus oryzae, whose saccharification abilities humans have harnessed for thousands of years to produce sake, soy sauce, and miso from starch-rich grains, and its wild relative A. flavus, a potentially toxigenic plant and animal pathogen [7]. We discovered dramatic changes in the sequence variation and abundance profiles of genes and wholesale primary and secondary metabolic pathways between domesticated and wild relative isolates during growth on rice. Our data suggest that, through selection by humans, an atoxigenic lineage of A. flavus gradually evolved into a "cell factory" for enzymes and metabolites involved in the saccharification process. These results suggest that whereas animal and plant domestication was largely driven by Neolithic "genetic tinkering" of developmental pathways, microbe domestication was driven by extensive remodeling of metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.