Evidence map›Paper›PMID 22795617›Full record

Trial reportPsychoneuroendocrinology2013

Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial.

David S Black, Steve W Cole, Michael R Irwin, Elizabeth Breen, Natalie M St Cyr, Nora Nazarian, Dharma S Khalsa, Helen Lavretsky

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06583395 (Effects Of Meditation On The Gut Microbiome And Human Health and Disease), which is not on this map. Cited by 131 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 9 pooled it
23.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06583395 enrolling by invitationnot on this mapstarted 2021, after this paper: background citation

Effects Of Meditation On The Gut Microbiome And Human Health and Disease

TypeobservationalSponsorTobias Moeller-BertramRan2021 to 2025Enrolled3,000ConditionsAmyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, AsthmaArmsAdvanced multi-component meditation practice
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 9 syntheses or guidelines pooled it, 247 citations in OpenAlex.

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  12. A randomized controlled trial of Kundalini yoga in mild cognitive impairment.International psychogeriatrics · 2017 · on this map
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

David S BlackCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA, USA.
Steve W Cole
Michael R Irwin
Elizabeth Breen
Natalie M St Cyr
Nora Nazarian
Dharma S Khalsa
Helen Lavretsky
University of California, Los Angeles · USNeurobehavioral Systems · USSalk Institute for Biological Studies · US

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2010
$74.3M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Chronic Moderate Sleep Restriction in Older Long and Older Average SleepersR01HL095799 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI IRWIN, MICHAEL R, JEAN-LOUIS, GIRARDIN · 2011 to 2015
$3.8M
Sleep and Immune Mechanisms in Rheumatoid ArthritisR01HL079955 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2009
$3.0M
Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsR01CA119159 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2010
$2.2M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Methylphenidate Use to Improve Outcomes in Geriatric DepressionR01MH077650 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2008 to 2012
$1.8M
Post-Graduate Training Program in Psychoneuroimmunology and Mental HealthT32MH019925 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 1997 to 2012
$1.7M
Combinatorial Genomics in CancerR01CA116778 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2006 to 2010
$1.5M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCCIH NIH HHS AT003480NCCIH NIH HHS R21 AT003480NCI NIH HHS R01 CA116778NCI NIH HHS R01-CA119159NCRR NIH HHS M01 RR000827NCRR NIH HHS M01 RR000865NHLBI NIH HHS R01 HL079955NHLBI NIH HHS R01-HL079955NHLBI NIH HHS R01 HL095799NIA NIH HHS P30 AG028748NIA NIH HHS P30-AG028748NIA NIH HHS R01 AG026364NIA NIH HHS R01-AG026364NIA NIH HHS R01 AG034588NIA NIH HHS R01-AG034588NIMH NIH HHS K24 MH086481NIMH NIH HHS MH077650NIMH NIH HHS MH086481NIMH NIH HHS R01 MH077650NIMH NIH HHS T32 MH019925
6 · The paper itself

Abstract

backgroundAlthough yoga and meditation have been used for stress reduction with reported improvement in inflammation, little is known about the biological mechanisms mediating such effects. The present study examined if a yogic meditation might alter the activity of inflammatory and antiviral transcription control pathways that shape immune cell gene expression.

methodsForty-five family dementia caregivers were randomized to either Kirtan Kriya Meditation (KKM) or Relaxing Music (RM) listening for 12 min daily for 8 weeks and 39 caregivers completed the study. Genome-wide transcriptional profiles were collected from peripheral blood leukocytes sampled at baseline and 8-week follow-up. Promoter-based bioinformatics analyses tested the hypothesis that observed transcriptional alterations were structured by reduced activity of the pro-inflammatory nuclear factor (NF)-κB family of transcription factors and increased activity of Interferon Response Factors (IRFs; i.e., reversal of patterns previously linked to stress).

resultsIn response to KKM treatment, 68 genes were found to be differentially expressed (19 up-regulated, 49 down-regulated) after adjusting for potentially confounded differences in sex, illness burden, and BMI. Up-regulated genes included immunoglobulin-related transcripts. Down-regulated transcripts included pro-inflammatory cytokines and activation-related immediate-early genes. Transcript origin analyses identified plasmacytoid dendritic cells and B lymphocytes as the primary cellular context of these transcriptional alterations (both p<.001). Promoter-based bioinformatic analysis implicated reduced NF-κB signaling and increased activity of IRF1 in structuring those effects (both p<.05).

conclusionA brief daily yogic meditation intervention may reverse the pattern of increased NF-κB-related transcription of pro-inflammatory cytokines and decreased IRF1-related transcription of innate antiviral response genes previously observed in healthy individuals confronting a significant life stressor.

Indexed as

CaregiversMeditationYogaDementiaFemaleGene Expression RegulationHumansInterferon Regulatory FactorsLeukocytesMaleMiddle AgedNF-kappa BTranscriptomeInterferon Regulatory FactorsNF-kappa B

Identifiers

PMID22795617
PMCPMC3494746
OpenAlexW2046214258

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.