ArticleDevelopmental cognitive neuroscience2012
The hemodynamic response in children with Simplex Autism.
Article in Developmental cognitive neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.Human brain mapping · 2017Trial
- Automatic diagnosis of autism spectrum disorders in children through resting-state functional magnetic resonance imaging with machine vision.Quantitative imaging in medicine and surgery · 2025Article
- Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders.Frontiers in cellular neuroscience · 2023Review
- Let's Play the fMRI-Advantages of Gamified Paradigm in Examining the Motor Cortex of Young Children.Journal of clinical medicine · 2022Article
- Antidepressant treatment, not depression, leads to reductions in behavioral and neural responses to pain empathy.Translational psychiatry · 2019Article
- Subtyping cognitive profiles in Autism Spectrum Disorder using a Functional Random Forest algorithm.NeuroImage · 2018Article
- How do antidepressants influence the BOLD signal in the developing brain?Developmental cognitive neuroscience · 2017Review
- The Lag Structure of Intrinsic Activity is Focally Altered in High Functioning Adults with Autism.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- How networks communicate: propagation patterns in spontaneous brain activity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Atypical processing of voice sounds in infants at risk for autism spectrum disorder.Cortex; a journal devoted to the study of the nervous system and behavior · 2015Article
- The potential of infant fMRI research and the study of early life stress as a promising exemplar.Developmental cognitive neuroscience · 2015Review
- Analysis of cortical shape in children with simplex autism.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Individual differences in symptom severity and behavior predict neural activation during face processing in adolescents with autism.NeuroImage. Clinical · 2015Article
- Differentiating neural reward responsiveness in autism versus ADHD.Developmental cognitive neuroscience · 2014Article
- The BOLD signal and neurovascular coupling in autism.Developmental cognitive neuroscience · 2013Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundNumerous functional magnetic resonance imaging (fMRI) studies of the brain-bases of autism have demonstrated altered cortical responses in subjects with autism, relative to typical subjects, during a variety of tasks. These differences may reflect altered neuronal responses or altered hemodynamic response. This study searches for evidence of hemodynamic response differences by using a simple visual stimulus and elementary motor actions, which should elicit similar neuronal responses in patients and controls.
methodsWe acquired fMRI data from two groups of 16 children, a typical group and a group with Simplex Autism, during a simple visuomotor paradigm previously used to assess this question in other cross-group comparisons. A general linear model estimated the blood-oxygen-level-dependent (BOLD) signal time course, and repeated-measures analysis of variance tested for potential cross-group differences in the BOLD signal.
resultsThe hemodynamic response in Simplex Autism is similar to that found in typical children. Although the sample size was small for a secondary analysis, medication appeared to have no effect on the hemodynamic response within the Simplex Autism group.
conclusionsWhen fMRI studies show BOLD response differences between autistic and typical subjects, these results likely reflect between-group differences in neural activity and not an altered hemodynamic response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.