ArticleThe Journal of pediatrics2013
Glucose control predicts 2-year change in lipid profile in youth with type 1 diabetes.
Article in The Journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association.Diabetes care · 2018Guideline
- Cardiovascular Disease and Dyslipidemia in Pediatric Type 1 Diabetes.Current atherosclerosis reports · 2026Review
- 14. Children and Adolescents: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- 14. Children and Adolescents: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- Preventing and Managing Vascular Complications in Adolescents With Type 1 Diabetes.Journal of diabetes research · 2025Review
- Optimizing lipid control in Taiwanese diabetic patients: A collaborative consensus by the Diabetes Association of the Republic of China (Taiwan) and the Taiwanese Association of Diabetes Educators.Journal of diabetes investigation · 2024Article
- Uric Acid Is Not Associated With Cardiovascular Health in Youth With Type 1 Diabetes: SEARCH for Diabetes in Youth Study.The Journal of clinical endocrinology and metabolism · 2024Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
- The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus.Diseases (Basel, Switzerland) · 2023Article
- Glycemic Control and Metabolic Parameters in Children and Adolescents With Type 1 Diabetes.Cureus · 2023Article
- Screening of lipids and kidney function in children and adolescents with Type 1 Diabetes: does age matter?Frontiers in endocrinology · 2023Article
- Sex-dependent effects of Canagliflozin on kidney protection in mice with combined hypertension-type 1 diabetes.PloS one · 2023Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2023.Diabetes care · 2023Review
- Are Clinicians Aggressive Enough in Treating Diabetes-Related Hyperlipidemia in Youth?Current atherosclerosis reports · 2022Review
- Breakfast consumption frequency is associated with dyslipidemia: a retrospective cohort study of a working population.Lipids in health and disease · 2022Article
- First Evaluation of P Dispersion and Tp-e Parameters in Electrocardiograms of Children with Diabetic KetoacidosisJournal of clinical research in pediatric endocrinology · 2022Article
- Joint 30-year HbA1c and lipid trajectories and mortality in type 1 diabetes.Diabetes research and clinical practice · 2022Article
- The Theory of Hyperlipidemic Memory of Type 1 Diabetes.Frontiers in endocrinology · 2022Article
- Dyslipidaemia in Type 1 Diabetes: Molecular Mechanisms and Therapeutic Opportunities.Biomedicines · 2021Review
- Twenty years of pediatric diabetes surveillance: what do we know and why it matters.Annals of the New York Academy of Sciences · 2021Review
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that a change in glycated hemoglobin (A1c) over a follow-up interval of approximately 2 years would be associated with concomitant changes in fasting lipids in individuals with type 1 diabetes (T1D). STUDY
designAll subjects with T1D diagnosed in 2002-2005 in the SEARCH for Diabetes in Youth study with at least 2 study visits ∼12 and ∼24 months after an initial visit were included (age at initial visit, 10.6 ± 4.1 years; 48% female; diabetes duration, 10 ± 7 months; 76% non-Hispanic white; A1c = 7.7% ± 1.4%). Longitudinal mixed models were fit to examine the relationship between change in A1c and change in lipid levels (total cholesterol [TC], high-density lipoprotein-cholesterol [HDL-c], low-density lipoprotein-cholesterol [LDL-c], log triglycerides [TG], and non-HDL-c) with adjustment for possible confounders.
resultsChange in A1c over time was significantly associated with changes in TC, HDL-c, LDL-c, TG, and non-HDL-c over the range of A1c values. For example, for a person with an A1c of 10% and then a 2% decrease in A1c 2 years later (to 8%), the model predicted concomitant changes in TC (-0.29 mmol/L, -11.4 mg/dL), HDL-c (0.03 mmol/L, 1.3 mg/dL), LDL-c (-0.23 mmol/L, -9.0 mg/dL), and non-HDL-c (-0.32 mmol/L, -12.4 mg/dL) and an 8.5% decrease in TG (mmol/L).
conclusionsImproved glucose control over a 2-year follow-up was associated with a more favorable lipid profile but may be insufficient to normalize lipids in dyslipidemic T1D youth needing to decrease lipids to goal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.