ArticleDrug and alcohol dependence2013
Accentuating effects of nicotine on ethanol response in mice with high genetic predisposition to ethanol-induced locomotor stimulation.
Article in Drug and alcohol dependence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Young adults report increased pleasure from using e-cigarettes and smoking tobacco cigarettes when drinking alcohol.Addictive behaviors · 2019Article
- Nicotine affects ethanol-conditioned taste, but not place, aversion in a simultaneous conditioning procedure.Alcohol (Fayetteville, N.Y.) · 2018Article
- Interactions between nicotine and drugs of abuse: a review of preclinical findings.The American journal of drug and alcohol abuse · 2017Review
- Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Glucocorticoid Regulation of Food-Choice Behavior in Humans: Evidence from Cushing's Syndrome.Frontiers in neuroscience · 2016Article
- Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism.Progress in molecular biology and translational science · 2016Review
- Effects of nicotine on ethanol-induced locomotor sensitization: A model of neuroadaptation.Behavioural brain research · 2015Article
- Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice.Psychopharmacology · 2015Article
- Nicotine enhances the locomotor stimulating but not the conditioned rewarding effect of ethanol in DBA/2J mice.Alcoholism, clinical and experimental research · 2015Article
- Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation, and sensitization.Alcoholism, clinical and experimental research · 2014Article
- Differences in the reinstatement of ethanol seeking with ganaxolone and gaboxadol.Neuroscience · 2014Article
- Unique genetic factors influence sensitivity to the rewarding and aversive effects of methamphetamine versus cocaine.Behavioural brain research · 2013Article
- Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: comparing D2L and D2S.Neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCo-morbid use of nicotine-containing tobacco products and alcohol is prevalent in alcohol dependent individuals. Common genetic factors could influence initial sensitivity to the independent or interactive effects of these drugs and play a role in their co-abuse.
methodsLocomotor sensitivity to nicotine and ethanol, alone and in combination, was assessed in mice bred for high (FAST) and low (SLOW) sensitivity to the locomotor stimulant effects of ethanol and in an inbred strain of mouse (DBA/2J) that has been shown to have extreme sensitivity to ethanol-induced stimulation in comparison to other strains.
resultsThe effects of nicotine and ethanol, alone and in combination, were dependent on genotype. In FAST and DBA/2J mice that show high sensitivity to ethanol-induced stimulation, nicotine accentuated the locomotor stimulant response to ethanol. This effect was not found in SLOW mice that are not stimulated by ethanol alone.
conclusionsThese data indicate that genes underlying differential sensitivity to the stimulant effects of ethanol alone also influence sensitivity to nicotine in combination with ethanol. Sensitivity to the stimulant effects of nicotine alone does not appear to predict the response to the drug combination, as FAST mice are sensitive to nicotine-induced stimulation, whereas SLOW and DBA/2J mice are not. The combination of nicotine and ethanol may have genotype-dependent effects that could impact co-abuse liability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.