Evidence map›Paper›PMID 22795046›Full record

Trial reportGeneral hospital psychiatry

Motivational enhancement therapy coupled with cognitive behavioral therapy versus brief advice: a randomized trial for treatment of hazardous substance use in pregnancy and after delivery.

Kimberly A Yonkers, Ariadna Forray, Heather B Howell, Nathan Gotman, Trace Kershaw, Bruce J Rounsaville, Kathleen M Carroll

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00227903 (Psychosocial Research to Improve Drug Treatment in Pregnancy), which is not on this map. Cited by 24 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 7 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00227903 phase2completednot on this map

Psychosocial Research to Improve Drug Treatment in Pregnancy (PRIDE-P)

TypeinterventionalSponsorYale UniversityRan2004 to 2010Enrolled168ConditionsAlcohol Abuse, Cocaine Abuse, Marijuana AbuseArmsMI-CBT, Brief Advice
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 7 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
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  4. More behavioral recommendations produce more change: A meta-analysis of efficacy of multibehavior recommendations to reduce nonmedical substance use.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
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  6. Identifying Effective Behavior Change Techniques for Alcohol and Illicit Substance Use During Pregnancy: A Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kimberly A YonkersDepartment of Psychiatry, the School of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA. Kimberly.Yonkers@yale.edu
Ariadna Forray
Heather B Howell
Nathan Gotman
Trace Kershaw
Bruce J Rounsaville
Kathleen M Carroll
Yale University · US

Funding

TSF to enhance treatment of cocaine dependenceP50DA009241 · NIDA · YALE UNIVERSITY · PI KOBER, HEDY · 1994 to 2018
$40.5M
SUBSTANCE ABUSEK12DA000167 · NIDA · YALE UNIVERSITY · PI STEPHANIE S O'MALLEY, Marc N Potenza · 1991 to 2026
$17.7M
Psychosocial Res. to Improve Drug Treatment in PregnancyR01DA019135 · NIDA · YALE UNIVERSITY · PI YONKERS, KIMBERLY A · 2004 to 2008
$2.4M
Progesterone for Postpartum Cocaine RelapseR21DA029914 · NIDA · YALE UNIVERSITY · PI SOFUOGLU, MEHMET, YONKERS, KIMBERLY A · 2010 to 2011
$448k
NIDA NIH HHS K12 DA000167NIDA NIH HHS P50 DA009241NIDA NIH HHS P50 DA09241NIDA NIH HHS R01 DA 019135NIDA NIH HHS R01 DA019135NIDA NIH HHS R21 DA029914
6 · The paper itself

Abstract

objectiveThe objective was to compare the efficacy of motivational enhancement therapy coupled with cognitive behavioral therapy (MET-CBT) to brief advice for treatment of substance use in pregnancy.

methodThis was a randomized, parallel, controlled trial that was yoked to prenatal care and delivered at hospital outpatient clinics. We enrolled 168 substance-using women who had not yet completed an estimated 28 weeks of pregnancy. Obstetrical clinicians provided brief advice, and study nurses administered manualized MET-CBT. The primary outcome was percentage of days in the prior 28 days in which alcohol and/or drugs were used immediately before and 3 months postdelivery.

resultsThere were no significant differences across groups in terms of self-reported percentage of days in which drugs or alcohol were used prior to and 3 months postdelivery. Biological measures showed similar results. There was a trend (P=.08) for lower risk of preterm birth among those who received MET-CBT.

conclusionsThe tested interventions had similar therapeutic effects. Hence, both treatments may be suitable for pregnant substance users, depending on the population, setting and provider availability. Interventions that are intensified after delivery may decrease postpartum "rebound" effects in substance misuse.

Indexed as

Cognitive Behavioral TherapyCounselingMotivationAdolescentAdultCombined Modality TherapyFemaleHumansPregnancyPregnancy ComplicationsSubstance-Related DisordersUnited StatesYoung Adult

Identifiers

PMID22795046
PMCPMC3428516
OpenAlexW2043808171

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.