Trial reportNeuron2012
Intact memory for irrelevant information impairs perception in amnesia.
Trial report in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Age-related impairment in a complex object discrimination task that engages perirhinal cortex.Hippocampus · 2012Trial
- Behavioural separation of face memory and face perception.Nature communications · 2026Article
- Complementary roles of the human perirhinal and the entorhinal cortex in the hippocampal retrieval of episodic memory.iScience · 2025Article
- Article
- Do cultural differences emerge at different levels of representational hierarchy?Memory & cognition · 2024Article
- Dissociation between area TE and rhinal cortex in accuracy vs. speed of visual categorization in rhesus monkeys.Frontiers in behavioral neuroscience · 2024Article
- Compensatory cognition in neurological diseases and aging: A review of animal and human studies.Aging brain · 2023Review
- Medial temporal lobe contributions to resting-state networks.Brain structure & function · 2022Article
- Perceptual and Semantic Representations at Encoding Contribute to True and False Recognition of Objects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Executive function and high ambiguity perceptual discrimination contribute to individual differences in mnemonic discrimination in older adults.Cognition · 2021Article
- Visual and Semantic Representations Predict Subsequent Memory in Perceptual and Conceptual Memory Tests.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Prior knowledge promotes hippocampal separation but cortical assimilation in the left inferior frontal gyrus.Nature communications · 2020Article
- Mechanisms of memory: An intermediate level of analysis and organization.Current opinion in behavioral sciences · 2020Article
- Precision, binding, and the hippocampus: Precisely what are we talking about?Neuropsychologia · 2020Article
- Visual working memory impairments for single items following medial temporal lobe damage.Neuropsychologia · 2019Article
- Alzheimer's pathology targets distinct memory networks in the ageing brain.Brain : a journal of neurology · 2019Article
- In sight, in mind.eLife · 2018Article
- Integrative and distinctive coding of visual and conceptual object features in the ventral visual stream.eLife · 2018Article
- Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Memory and perception have long been considered separate cognitive processes, and amnesia resulting from medial temporal lobe (MTL) damage is thought to reflect damage to a dedicated memory system. Recent work has questioned these views, suggesting that amnesia can result from impoverished perceptual representations in the MTL, causing an increased susceptibility to interference. Using a perceptual matching task for which fMRI implicated a specific MTL structure, the perirhinal cortex, we show that amnesics with MTL damage including the perirhinal cortex, but not those with damage limited to the hippocampus, were vulnerable to object-based perceptual interference. Importantly, when we controlled such interference, their performance recovered to normal levels. These findings challenge prevailing conceptions of amnesia, suggesting that effects of damage to specific MTL regions are better understood not in terms of damage to a dedicated declarative memory system, but in terms of impoverished representations of the stimuli those regions maintain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.