ArticleMolecular cytogenetics2012
Array-based comparative genomic hybridization is more informative than conventional karyotyping and fluorescence in situ hybridization in the analysis of first-trimester spontaneous abortion.
Article in Molecular cytogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Copy number variations in spontaneous abortions: a meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Miscarriage Tissue Research: Still in Its Infancy.Life (Basel, Switzerland) · 2026Review
- Chromosomal Abnormalities in Miscarriages and Maternal Age: New Insights from the Study of 7118 Cases.Cells · 2024Article
- The chromosomal characteristics of spontaneous abortion and its potential associated copy number variants and genes.Journal of assisted reproduction and genetics · 2024Article
- Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis.Annals of medicine · 2023Article
- Application of array comparative genomic hybridization (aCGH) for identification of chromosomal aberrations in the recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2022Article
- Characterization of Copy-Number Variations and Possible Candidate Genes in Recurrent Pregnancy Losses.Genes · 2021Article
- Genetic analysis of products of conception using a HLPA/SNP-array strategy.Molecular cytogenetics · 2019Article
- Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- Cytogenetic analysis of spontaneously discharged products of conception by array-based comparative genomic hybridization.SpringerPlus · 2016Article
- The Diagnosis of Choriocarcinoma in Molar Pregnancies: A Revised Approach in Clinical Testing.Journal of clinical medicine research · 2015Article
- Genomic characteristics of miscarriage copy number variants.Molecular human reproduction · 2015Article
- 1(st) trimester miscarriage: four decades of study.Translational pediatrics · 2015Review
- Rescue karyotyping: a case series of array-based comparative genomic hybridization evaluation of archival conceptual tissue.Reproductive biology and endocrinology : RB&E · 2014Article
- Best diagnostic approach for the genetic evaluation of fetuses after intrauterine death in first, second or third trimester: QF-PCR, karyotyping and/or genome wide SNP array analysis.Molecular cytogenetics · 2014Article
- Genetic effects of a 13q31.1 microdeletion detected by noninvasive prenatal testing (NIPT).International journal of clinical and experimental pathology · 2014Article
- Diagnostic utility of novel combined arrays for genome-wide simultaneous detection of aneuploidy and uniparental isodisomy in losses of pregnancy.Molecular cytogenetics · 2014Article
- Chromosome aberrations in a large series of spontaneous miscarriages in the German population and review of the literature.Molecular cytogenetics · 2014Article
- Abnormalities in spontaneous abortions detected by G-banding and chromosomal microarray analysis (CMA) at a national reference laboratory.Molecular cytogenetics · 2014Article
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10 authors.
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Abstract
backgroundArray-based comparative genomic hybridization (aCGH) is a new technique for detecting submicroscopic deletions and duplications, and can overcome many of the limitations associated with classic cytogenetic analysis. However, its clinical use in spontaneous abortion needs comprehensive evaluation. We used aCGH to investigate chromosomal imbalances in 100 spontaneous abortions and compared the results with G-banding karyotyping and fluorescence in situ hybridization (FISH). Inconsistent results were verified by quantitative fluorescence PCR.
resultsAbnormalities were detected in 61 cases. aCGH achieved the highest detection rate (93.4%, 57/61) compared with traditional karyotyping (77%, 47/61) and FISH analysis (68.9%, 42/61). aCGH identified all chromosome abnormalities reported by traditional karyotyping and interphase FISH analysis, with the exception of four triploids. It also detected three additional aneuploidy cases in 37 specimens with 'normal' karyotypes, one mosaicism and 10 abnormalities in 14 specimens that failed to grow in vitro.
conclusionsaCGH analysis circumvents many limitations in traditional karyotyping or FISH. The accuracy and efficiency of aCGH in spontaneous abortions highlights its clinical usefulness for the future. As aborted tissues have the potential to be contaminated with maternal cells, the threshold value of detection in aCGH should be lowered to avoid false negatives.
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