ReviewThe Medical clinics of North America2012
Contribution of the environment and comorbidities to chronic obstructive pulmonary disease phenotypes.
Review in The Medical clinics of North America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.BMC pulmonary medicine · 2014Trial
- Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort.Respiratory research · 2014Trial
- Taking Healthy Steps: rationale, design and baseline characteristics of a randomized trial of a pedometer-based Internet-mediated walking program in veterans with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2014Trial
- Sociodemographic Determinants of Hospitalized Exacerbations in Exposure-Defined COPD Phenotypes: A Nationwide Prospective Cohort Study in China.International journal of chronic obstructive pulmonary disease · 2026Article
- Exploring the silent connection: unveiling the intricate relationship between gastroesophageal reflux disease and sleep apnea syndrome.Human genomics · 2025Article
- Potential Causal Relationship Between Chronic Obstructive Pulmonary Disease and Diabetes: A Bidirectional Two-Sample Mendelian Randomization Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Risk of Cardiovascular Events Associated with Chronic Obstructive Pulmonary Disease and/or Metabolic Syndrome: A Large-Scale Nationwide Population-Based Cohort Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Review
- New-onset atrial fibrillation in critically ill patients with coronavirus disease 2019 (COVID-19).Journal of arrhythmia · 2021Article
- Analysis of prevalence and prognosis of type 2 diabetes mellitus in patients with acute exacerbation of COPD.BMC pulmonary medicine · 2021Observational
- Management of cardiovascular comorbidities in chronic obstructive pulmonary disease patients.Journal of thoracic disease · 2020Review
- Ursolic Acid Protected Lung of Rats From Damage Induced by Cigarette Smoke Extract.Frontiers in pharmacology · 2019Article
- GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease.Respiratory research · 2017Observational
- Gastroesophageal reflux disease symptoms in the Greek general population: prevalence and risk factors.Clinical and experimental gastroenterology · 2016Article
- Implications of the GOLD COPD Classification and Guidelines.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2015Article
- The RESPECT study: RESearch on the PrEvalence and the diagnosis of COPD and its Tobacco-related etiology: a study protocol.BMC public health · 2015Article
- Article
- Chronic obstructive pulmonary disease, cognitive impairment, and development of disability: the health and retirement study.Annals of the American Thoracic Society · 2014Article
- Inflammasome Activity in Non-Microbial Lung Inflammation.Journal of environmental immunology and toxicology · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
* COPD is a heterogeneous disease, modified by environmental and intrinsic host factors. The interaction between COPD and its comorbidities is complex and bidirectional. * It has been estimated that the proportion of patients with COPD caused by cigarette smoking is between 80% and 90%. Risk factors associated with COPD in nonsmokers are numerous and incompletely understood, but a history of asthma or tuberculosis, exposure to traffic and outdoor pollution, and exposure to biomass smoke show the strongest associations. Other factors that may contribute to COPD phenotypes include gender, genetics, and the lung microbiome. * Certain comorbid conditions, such as cardiovascular disease and osteoporosis, are more common in the COPD patient population. Other comorbidities, such as overlap syndrome, the coexistence of COPD, and obstructive sleep apnea may not be as prevalent in COPD but are important because they may modify disease course. * Systemic inflammation may be pathogenically related to many comorbidities seen in COPD including cardiovascular disease, osteoporosis, metabolic syndrome, and depression. * Based on the data presented here, two general patterns of clinical features and comorbidities that share some associations are (1) emphysema, low BMI and osteoporosis and (2) chronic bronchitis, airway disease, high BMI, OSA, and diabetes. * The classification of patients with COPD into subgroups with shared characteristics and outcomes offers the potential for specific interventions. New research tools from the fields of epidemiology, immunology, imaging, and data analysis will be helpful in accomplishing this goal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.