ArticlePloS one2012
Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Long-term potentiation and long-term depression are both impaired afterBiomedical physics & engineering express · 2025Article
- Synaptic memory and CaMKII.Physiological reviews · 2023Review
- Synapse integrity and function: Dependence on protein synthesis and identification of potential failure points.Frontiers in molecular neuroscience · 2022Article
- The content of hippocampal "replay".Hippocampus · 2020Review
- Paradoxical LTP maintenance with inhibition of protein synthesis and the proteasome suggests a novel protein synthesis requirement for early LTP reversal.Journal of theoretical biology · 2018Article
- AMPA Receptor Trafficking for Postsynaptic Potentiation.Frontiers in cellular neuroscience · 2018Review
- Significance of Low Nanomolar Concentration of ZnMolecular neurobiology · 2017Review
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- Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- A molecular brake controls the magnitude of long-term potentiation.Nature communications · 2014Article
- The roles of protein expression in synaptic plasticity and memory consolidation.Frontiers in molecular neuroscience · 2014Review
- Oxidative stress and neurodegenerative disorders.International journal of molecular sciences · 2013Review
- Long-term potentiation: peeling the onion.Neuropharmacology · 2013Review
- Improved preparation and preservation of hippocampal mouse slices for a very stable and reproducible recording of long-term potentiation.Journal of visualized experiments : JoVE · 2013Article
- Estrogen promotes learning-related plasticity by modifying the synaptic cytoskeleton.Neuroscience · 2013Review
- Article
- Mechanisms of memory enhancement.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current thinking about LTP triggered in the area CA1 of hippocampal slices is ruled by two "dogmas": (1) A single train of high-frequency stimulation is sufficient to trigger short-lasting LTP (1-3 h), whereas multiple trains are required to induce long-lasting LTP (L-LTP, more than 4 h). (2) The development of the late phase of L-LTP requires the synthesis of new proteins. In this study, we found that a single high-frequency train could trigger an LTP lasting more than 8 h that was not affected by either anisomycin or cycloheximide (two inhibitors of protein synthesis). We ascertained that the induction of this L-LTP made use of the same mechanisms as those usually reported to be involved in LTP induction: it was dependent on NMDA receptors and on the activation of two "core" kinases, CaMKII and PI3K. These findings call into question the two "dogmas" about LTP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.