ArticlePloS one2012
Relationship between periodontitis-related antibody and frequent exacerbations in chronic obstructive pulmonary disease.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- The impact of gingivitis reduction on lung function: a randomized trial under intensified oral hygiene.Trials · 2023Trial
- Relationship between periodontitis and systemic health conditions: a narrative review.Ewha medical journal · 2025Review
- An Assessment of Periodontal Status and Oral Hygiene in Patients with Hypertension in the South-West Region of Romania.Biomedicines · 2025Article
- Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort Study.Journal of pharmacy & bioallied sciences · 2024Article
- Article
- Association between periodontal disease and chronic obstructive pulmonary disease.The Japanese dental science review · 2023Review
- Putative Bidirectionality of Chronic Obstructive Pulmonary Disease and Periodontal Disease: A Review of the Literature.Journal of clinical medicine · 2023Review
- PeriodontopathogensPathogens (Basel, Switzerland) · 2023Review
- Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease Risk.Journal of clinical medicine · 2022Article
- Porphyromonas gingivalis outside the oral cavity.Odontology · 2022Review
- Impact of Non-surgical Periodontal Therapy on Pulmonary functions, Periodontal Health and Salivary Matrix Metalloproteinase-8 of COPD Patients with Chronic Periodontitis: A Clinico-biochemical Study.Turkish thoracic journal · 2021Article
- Low serum free light chain is associated with risk of COPD exacerbation.ERJ open research · 2020Article
- The relationship between oral health and COPD exacerbations.International journal of chronic obstructive pulmonary disease · 2019Article
- Prediction models for exacerbations in patients with COPD.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Altered antigenic profiling and infectivity of Porphyromonas gingivalis in smokers and non-smokers with periodontitis.Journal of periodontology · 2014Article
- Understanding low COPD exacerbation rates in Japan: a review and comparison with other countries.International journal of chronic obstructive pulmonary diseaseReview
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo identify patients with chronic obstructive pulmonary disease (COPD) who are susceptible to frequent exacerbations is important. Although periodontitis aggravated by poor oral hygiene might increase the risk of lower respiratory tract infection, the relationship between periodontitis and COPD exacerbations remains unknown. This prospective cohort study investigates the relationship between periodontitis-related antibody and exacerbation frequency over a one-year period.
methodsWe assessed an IgG antibody titer against Porphyromonas gingivalis, which is a major pathogen of periodontitis, and then prospectively followed up 93 individuals over one year to detect exacerbations.
resultsThe numbers of exacerbations and the rate of individuals with frequent exacerbations (at least two per year) were significantly lower in patients with higher IgG titer than those with normal IgG titer (0.8 vs. 1.2 per year, p= 0.045 and 14.3 vs. 38.6%, p= 0.009, respectively). Multivariate logistic regression analysis showed that being normal-IgG titer for periodontitis-related antibody significantly increased the risk of frequent exacerbations (relative risk, 5.27, 95% confidence interval, 1.30-25.7; p = 0.019) after adjusting for other possible confounders, such as a history of exacerbations in the past year, disease severity, COPD medication and smoking status.
conclusionsNormal-IgG titer for periodontitis-related antibody can be an independent predictor of frequent exacerbations. Measuring periodontitis-related antibody titers might be useful to identify patients with susceptibility to frequent exacerbations so that an aggressive prevention strategy can be designed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.