ArticlePloS one2012
Comparative genotypic and phenotypic characterisation of methicillin-resistant Staphylococcus aureus ST398 isolated from animals and humans.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Immunoproteomic analysis of the serum IgG response to cell wall-associated proteins of Staphylococcus aureus strains belonging to CC97 and CC151.Veterinary research · 2023Article
- Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives.BMC veterinary research · 2022Review
- Antimicrobial resistance in the globalized food chain: a One Health perspective applied to the poultry industry.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- Comparison of Virulence Patterns BetweenFrontiers in veterinary science · 2022Article
- Emergence of Thymidine-Dependent Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Patients in Southern Brazil.Microbiology spectrum · 2021Article
- Genomic Analysis ofFrontiers in microbiology · 2021Article
- Livestock-Associated Methicillin-ResistantFrontiers in microbiology · 2019Article
- Comparative Secretome Analyses of Human and ZoonoticMolecular & cellular proteomics : MCP · 2018Article
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
- Virulence gene profiles: alpha-hemolysin and clonal diversity in Staphylococcus aureus isolates from bovine clinical mastitis in China.BMC veterinary research · 2018Article
- Transmission of highly virulent community-associated MRSA ST93 and livestock-associated MRSA ST398 between humans and pigs in Australia.Scientific reports · 2017Article
- Prevalence, Virulence Genes, Antimicrobial Susceptibility, and Genetic Diversity ofFrontiers in microbiology · 2017Article
- Comparative virulence studies and transcriptome analysis of Staphylococcus aureus strains isolated from animals.Scientific reports · 2016Article
- Evidence for adaptation of porcine Toll-like receptors.Immunogenetics · 2016Article
- Characterization of Methicillin-ResistantFrontiers in microbiology · 2016Article
- Livestock-Associated Methicillin ResistantFrontiers in microbiology · 2016Article
- Dose-response relationship between antimicrobial drugs and livestock-associated MRSA in pig farming.Emerging infectious diseases · 2015Article
- Characterization of Insertion Sequence ISSau2 in the Human and Livestock-Associated Staphylococcus aureus.PloS one · 2015Article
- Extensive Genomic Diversity among Bovine-Adapted Staphylococcus aureus: Evidence for a Genomic Rearrangement within CC97.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) ST398 among pigs in certain European countries and North America and its occurrence in other animal species raises a question concerning the molecular mechanisms mediating the success of this lineage. In this study a panel of S. aureus strains belonging to sequence type (ST) 5 (n = 4), ST8 (n = 5), ST15 (n = 5), ST22 (n = 8), clonal complex (CC) 30 (n = 8), CC97 (n = 8), CC130 (n = 4), CC151 (n = 4) and ST398 (n = 18) were screened by DNA microarray and PCR for the carriage of virulence and antimicrobial resistance genes. Isolates belonging to the same sequence type/clonal complex (ST/CC) were found to share similar virulence gene profiles. The ST398 lineage displayed the lowest content of virulence genes, which consisted mainly of genes detected among the majority or all of the analysed lineages. All MRSA ST398 isolates lacked accessory virulence genes that were detected in other ST/CC. In contrast to virulence genotype, the antimicrobial resistance genes profiles varied between isolates belonging to the same ST/CC and profile similarities could be observed for isolates from different lineages. MRSA ST398 isolates in particular displayed significant diversity and high content of antimicrobial resistance genes. This was comparable with certain MRSA belonging to other sequence types particularly the equine MRSA ST8. The apparent lack of significant virulence genes among MRSA ST398 strains, demonstrates that the lineage features a unique genetic background but no ST398-specific virulence markers could be identified.
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