ArticlePloS one2012
Understanding the melanocyte distribution in human epidermis: an agent-based computational model approach.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Recent advances in gene delivery for melanocyte-associated disorders.Advanced drug delivery reviews · 2025Review
- Emerging cell-based and cell-free therapeutic strategies for vitiligo.Journal of translational autoimmunity · 2025Review
- Natural protection against oxidative stress in human skin melanocytes.Communications biology · 2025Review
- The Inhibitory Effect of Peptide Hydrolysate of Type I Collagen Derived from Pig Skin on Melanogenesis in B16F10 Melanoma Cells.Biomolecules · 2025Article
- Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix and Model Flexibility for Nuanced and Accurate Skin Studies.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Melanin Biopolymers in Pharmacology and Medicine-Skin Pigmentation Disorders, Implications for Drug Action, Adverse Effects and Therapy.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Current Status of Cell-Based Therapies for Vitiligo.International journal of molecular sciences · 2023Review
- Reproduction of patterns in melanocytic proliferations by agent-based simulation and geometric modeling.PLoS computational biology · 2021Article
- Screening of integrins localized on the surface of human epidermal melanocytes.In vitro cellular & developmental biology. Animal · 2020Article
- Uncertainty quantification on a spatial Markov-chain model for the progression of skin cancer.Journal of mathematical biology · 2020Article
- A Review of Key Biological and Molecular Events Underpinning Transformation of Melanocytes to Primary and Metastatic Melanoma.Cancers · 2019Review
- Tobramycin Promotes Melanogenesis by Upregulating p38 MAPK Protein Phosphorylation in B16F10 Melanoma Cells.Antibiotics (Basel, Switzerland) · 2019Article
- Microbiota and Immune-Mediated Skin Diseases-An Overview.Microorganisms · 2019Review
- Mitochondria's Role in Skin Ageing.Biology · 2019Review
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- Melanocytes in the skin--comparative whole transcriptome analysis of main skin cell types.PloS one · 2014Article
- Senescent fibroblasts in melanoma initiation and progression: an integrated theoretical, experimental, and clinical approach.Cancer research · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The strikingly even color of human skin is maintained by the uniform distribution of melanocytes among keratinocytes in the basal layer of the human epidermis. In this work, we investigated three possible hypotheses on the mechanism by which the melanocytes and keratinocytes organize themselves to generate this pattern. We let the melanocyte migration be aided by (1) negative chemotaxis due to a substance produced by the melanocytes themselves, or (2) positive chemotaxis due to a substance produced by keratinocytes lacking direct physical contact with a melanocyte, or (3) positive chemotaxis due to a substance produced by keratinocytes in a distance-to-melanocytes dependent manner. The three hypotheses were implemented in an agent-based computational model of cellular interactions in the basal layer of the human epidermis. We found that they generate mutually exclusive predictions that can be tested by existing experimental protocols. This model forms a basis for further understanding of the communication between melanocytes and other skin cells in skin homeostasis.
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Registered trials
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