ArticlePloS one2012
Immunohistochemical detection of TAS2R38 protein in human taste cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Cell surface localization of receptors considered nonfunctional and orphan bitter taste receptors.Current research in food science · 2026Article
- Exploring the Molecular Space of Bitter Peptides via Sensory, Receptor, and Sequence Data.Journal of agricultural and food chemistry · 2025Article
- Bitter taste receptors.Chemical senses · 2025Review
- Human Gingival Fibroblasts as a Novel Cell Model Describing the Association between Bitter Taste Thresholds and Interleukin-6 Release.Journal of agricultural and food chemistry · 2023Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Detection of Bitterness in Vitamins Is Mediated by the Activation of Bitter Taste Receptors.Nutrients · 2022Article
- Bitter taste receptor T2R38 is expressed on skin-infiltrating lymphocytes and regulates lymphocyte migration.Scientific reports · 2022Article
- An update on extra-oral bitter taste receptors.Journal of translational medicine · 2021Review
- Expression of TAS2R14 in the intestinal endocrine cells of non-human primates.Genes & genomics · 2021Article
- NIH Workshop Report: sensory nutrition and disease.The American journal of clinical nutrition · 2021Article
- Expression of Bitter Taste Receptors in the Intestinal Cells of Non-Human Primates.International journal of molecular sciences · 2020Article
- Spectroscopic Studies on the Biomolecular Recognition of Toluidine Blue: Key Information Towards Development of a Non-Contact, Non-Invasive Device for Oral Cancer Detection.Frontiers in oncology · 2020Article
- Expression of Bitter Taste Receptors and Solitary Chemosensory Cell Markers in the Human Sinonasal Cavity.Chemical senses · 2019Article
- Tissue-Dependent Expression of Bitter Receptor TAS2R38 mRNA.Chemical senses · 2019Article
- Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells.Pathogens and disease · 2016Article
- Article
- Expression and Functional Activity of the Human Bitter Taste Receptor TAS2R38 in Human Placental Tissues and JEG-3 Cells.Molecules (Basel, Switzerland) · 2016Article
- A role for airway taste receptor modulation in the treatment of upper respiratory infections.Expert review of respiratory medicine · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sense of taste plays an important role in the evaluation of the nutrient composition of consumed food. Bitter taste in particular is believed to serve a warning function against the ingestion of poisonous substances. In the past years enormous progress was made in the characterization of bitter taste receptors, including their gene expression patterns, pharmacological features and presumed physiological roles in gustatory as well as in non-gustatory tissues. However, due to a lack in TAS2R-specifc antibodies the localization of receptor proteins within gustatory tissues has never been analyzed. In the present study we have screened a panel of commercially available antisera raised against human bitter taste receptors by immunocytochemical experiments. One of these antisera was found to be highly specific for the human bitter taste receptor TAS2R38. We further demonstrate that this antibody is able to detect heterologously expressed TAS2R38 protein on Western blots. The antiserum is, however, not able to interfere significantly with TAS2R38 function in cell based calcium imaging analyses. Most importantly, we were able to demonstrate the presence of TAS2R38 protein in human gustatory papillae. Using double immunofluorescence we show that TAS2R38-positive cells form a subpopulation of PLCbeta2 expressing cells. On a subcellular level the localization of this bitter taste receptor is neither restricted to the cell surface nor particularly enriched at the level of the microvilli protruding into the pore region of the taste buds, but rather evenly distributed over the entire cell body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.