ArticlePloS one2012
Functional study of mammalian Neph proteins in Drosophila melanogaster.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025Review
- Evaluation of the synapse adhesion molecule Kirrel3 in neurological disease.Frontiers in neurology · 2025Review
- Insights into human kidney function from the study of Drosophila.Pediatric nephrology (Berlin, Germany) · 2023Review
- Exploring the relevance of NUP93 variants in steroid-resistant nephrotic syndrome using next generation sequencing and a fly kidney model.Pediatric nephrology (Berlin, Germany) · 2022Article
- Article
- Drosophila melanogaster: a simple genetic model of kidney structure, function and disease.Nature reviews. Nephrology · 2022Review
- MOLECULAR DESIGN OF THE KIDNEY FILTRATION BARRIER.Transactions of the American Clinical and Climatological Association · 2020Article
- A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies.PLoS genetics · 2018Article
- Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes.Experimental cell research · 2018Article
- Experimental Models to Study Podocyte Biology: Stock-Taking the Toolbox of Glomerular Research.Frontiers in pediatrics · 2018Review
- Modeling Monogenic Human Nephrotic Syndrome in theJournal of the American Society of Nephrology : JASN · 2017Article
- Using theFrontiers in pediatrics · 2017Review
- Podocyte-actin dynamics in health and disease.Nature reviews. Nephrology · 2016Review
- Article
- Molecular understanding of the slit diaphragm.Pediatric nephrology (Berlin, Germany) · 2013Review
- The podocyte slit diaphragm--from a thin grey line to a complex signalling hub.Nature reviews. Nephrology · 2013Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Neph molecules are highly conserved immunoglobulin superfamily proteins (IgSF) which are essential for multiple morphogenetic processes, including glomerular development in mammals and neuronal as well as nephrocyte development in D. melanogaster. While D. melanogaster expresses two Neph-like proteins (Kirre and IrreC/Rst), three Neph proteins (Neph1-3) are expressed in the mammalian system. However, although these molecules are highly abundant, their molecular functions are still poorly understood. Here we report on a fly system in which we overexpress and replace endogenous Neph homologs with mammalian Neph1-3 proteins to identify functional Neph protein networks required for neuronal and nephrocyte development. Misexpression of Neph1, but neither Neph2 nor Neph3, phenocopies the overexpression of endogenous Neph molecules suggesting a functional diversity of mammalian Neph family proteins. Moreover, structure-function analysis identified a conserved and specific Neph1 protein motif that appears to be required for the functional replacement of Kirre. Hereby, we establish D. melanogaster as a genetic system to specifically model molecular Neph1 functions in vivo and identify a conserved amino acid motif linking Neph1 to Drosophila Kirre function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.