ArticlePloS one2012
The role of serotonin in sleep disordered breathing associated with Parkinson disease: a correlative [11C]DASB PET imaging study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.Sleep medicine reviews · 2017Pooled it
- Meta-analysis of the prevalence of obstructive sleep apnea and associated risk factors among Parkinson's disease.Sleep and biological rhythms · 2025Review
- Daytime sleepiness in Parkinson's disease: a multifaceted symptom.Frontiers in sleep · 2023Review
- Multidirectional associations between the gut microbiota and Parkinson's disease, updated information from the perspectives of humoral pathway, cellular immune pathway and neuronal pathway.Frontiers in cellular and infection microbiology · 2023Review
- Respiratory Abnormalities in Parkinson's Disease: What Do We Know from Studies in Humans and Animal Models?International journal of molecular sciences · 2022Review
- Excessive Daytime Sleepiness in Parkinson's Disease.Nature and science of sleep · 2022Review
- Engrafted primary type-2 astrocytes improve the recovery of the nigrostriatal pathway in a rat model of Parkinson's disease.Molecular and cellular biochemistry · 2021Article
- Changes to Ventilation, Vocalization, and Thermal Nociception in the Pink1-/- Rat Model of Parkinson's Disease.Journal of Parkinson's disease · 2020Article
- Serotonergic dysregulation is linked to sleep problems in Parkinson's disease.NeuroImage. Clinical · 2018Article
- Sleep Disturbances in the Prodromal Stage of Parkinson Disease.Current treatment options in neurology · 2017Review
- Neuroimaging in Parkinson disease: from research setting to clinical practice.Nature reviews. Neurology · 2014Review
- Imaging the aetiology of sleep disorders in dementia and Parkinson's disease.Current neurology and neuroscience reports · 2014Review
- Sleep/wake problems in Parkinson's disease: pathophysiology and clinicopathologic correlations.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Daytime sleepiness in Parkinson's disease: a reappraisal.PloS one · 2014Article
- Insomnia and sleepiness in Parkinson disease: associations with symptoms and comorbidities.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2013Article
- Obstructive sleep apnea and neurodegenerative diseases: A bidirectional relation.Dementia & neuropsychologiaReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Sleep dysfunction and excessive daytime sleepiness are common in Parkinson disease (PD). Several studies suggest that PD patients exhibit high prevalence of sleep-disordered breathing (SDB). PD has a complex profile of neurochemical deficits in which abnormalities of different neurotransmitter systems may play significant and differing roles in the development of non-motor features. In the present study, we investigated whether SDB in PD is related to serotoninergic neuron degeneration. We used a cross-sectional design to assess the correlation between SDB and measures of caudal brainstem serotonin neuron integrity. Fifty one PD participants with mean disease duration of 6.0 (SD 3.7) years and mean age of 63.9 (SD 6.2) years were studied. We measured caudal brainstem serotoninergic innervation with [(11)C]DASB positron emission tomography (PET) imaging and striatal dopaminergic innervation with [(11)C]DTBZ PET imaging. SDB was assessed with polysomnography (PSG) and sleepiness with multiple sleep latency tests. Greater than half of participants exhibited PSG evidence of significant SDB; 12 participants had normal PSGs, 6 had mild SDB, 20 had moderate SDB, and 13 had severe SDB. We found no association between severity of SDB and caudal brainstem serotoninergic innervation in PD participants. Striatal dopaminergic denervation did not correlate with severity of SDB. We did find significant correlations between measures of motor function impairment and sleep quantity and quality in PD. Neither serotoninergic nor dopaminergic neuron degeneration is likely to play a major role in SDB observed in PD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.