ArticlePloS one2012
Hsp72 overexpression accelerates the recovery from caerulein-induced pancreatitis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review).Biomedical reports · 2025Review
- Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis.Frontiers in cellular and infection microbiology · 2022Review
- Kynurenic Acid and Its Analogue SZR-72 Ameliorate the Severity of Experimental Acute Necrotizing Pancreatitis.Frontiers in immunology · 2021Article
- Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling.Journal of hepatology · 2018Article
- Hsp90 regulation affects the treatment of glucocorticoid for pancreatitis-induced lung injury.Molecular and cellular biochemistry · 2018Article
- Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report.Gastroenterology research and practice · 2018Review
- Article
- Acute pancreatitis: the stress factor.World journal of gastroenterology · 2014Review
- Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents.Laboratory investigation; a journal of technical methods and pathology · 2014Review
- Modulation of protein quality control systems by food phytochemicals.Journal of clinical biochemistry and nutrition · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsHeat shock protein (Hsp) 72 is a molecular chaperone which is upregulated in response to a variety of stress situations and has a general cytoprotective function. Increased Hsp72 levels were implicated in protection from acute pancreatitis; a hypothesis which was not tested in a transgenic mouse model yet.
methodsTo analyze the role of Hsp72 during acute pancreatitis, well-characterized transgenic animals overexpressing rat Hsp72 (Hsp72 mice) under the control of the ß-actin promoter were subjected to caerulein- and L-arginine-induced acute pancreatitis. The severity of experimental pancreatitis was determined via serum lipase levels, morphometric evaluation and quantification of pancreatic edema/inflammation.
resultsHsp72 mice displayed ∼100-times Hsp72 overexpression, but no changes in the remaining chaperones. Robust Hsp72 signal was observed in pancreatic acini, but not in islets or ductal cells. In both models, elevated Hsp72 did not protect from development of acute pancreatitis and the pancreatitis-associated lung injury, but accelerated recovery from caerulein-induced tissue injury (lower lipase levels, edema, inflammation and necrosis 36 h after caerulein administration). The observed protective function of Hsp72 in caerulein-induced pancreatitis is likely due to an attenuated NF-κB signalling.
conclusionsHsp72 overexpression accelerates the recovery from acute pancreatitis and may represent a potential treatment strategy.
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