ArticlePloS one2012
Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- 40-Hz auditory stimulation for intracranial interictal activity: A pilot study.Acta neurologica Scandinavica · 2021Trial
- Disruption of brain rhythms in a pharmacological model of schizophrenia in male and female mice.Biology of sex differences · 2025Article
- How musicality enhances top-down and bottom-up selective attention: Insights from precise separation of simultaneous neural responses.Science advances · 2025Article
- Common Genomic and Proteomic Alterations Related to Disturbed Neural Oscillatory Activity in Schizophrenia.International journal of molecular sciences · 2025Review
- Explainable AI for Bipolar Disorder Diagnosis Using Hjorth Parameters.Diagnostics (Basel, Switzerland) · 2025Article
- Prefrontal Excitation/ Inhibition Balance Supports Adolescent Enhancements in Circuit Signal to Noise Ratio.bioRxiv : the preprint server for biology · 2024Article
- Network resonance and the auditory steady state response.Scientific reports · 2024Article
- The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders.Life (Basel, Switzerland) · 2024Review
- Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder.BMC psychiatry · 2023Article
- Cortical representation of speech temporal information through high gamma-band activity and its temporal modulation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.Translational psychiatry · 2023Article
- Effect of steady-state response versus excitatory/inhibitory balance on spiking synchronization in neural networks with log-normal synaptic weight distribution.Cognitive neurodynamics · 2022Article
- Aberrant Gamma-Band Oscillations in Mice with Vitamin D Deficiency: Implications on Schizophrenia and its Cognitive Symptoms.Journal of personalized medicine · 2022Article
- Decreased BOLD signals elicited by 40-Hz auditory stimulation of the right primary auditory cortex in bipolar disorder: An fMRI study.Frontiers in psychiatry · 2022Article
- Individual Resonant Frequencies at Low-Gamma Range and Cognitive Processing Speed.Journal of personalized medicine · 2021Article
- Neural network dynamics underlying gamma synchronization deficits in schizophrenia.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- 40-Hz Auditory Steady-State Response (ASSR) as a Biomarker of Genetic Defects in theInternational journal of molecular sciences · 2021Article
- Gamma-Range Auditory Steady-State Responses and Cognitive Performance: A Systematic Review.Brain sciences · 2021Review
- The Auditory Steady-State Response: Electrophysiological Index for Sensory Processing Dysfunction in Psychiatric Disorders.Frontiers in psychiatry · 2021Review
- Active probing to highlight approaching transitions to ictal states in coupled neural mass models.PLoS computational biology · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodic auditory click stimulation has been reported to elicit an auditory steady state response (ASSR). The ASSR has been suggested to reflect the efficiency of γ-amino butyric acid (GABA) inhibitory interneuronal activity. Although a potential role for GABAergic dysfunction has been previously proposed, the role of neural synchronization in the ASSR in people with bipolar disorder (BD) has received little attention. In the current study, we investigated ASSRs to 20 Hz, 30 Hz, 40 Hz and 80 Hz click trains in BD patients. A total of 14 (4 males) BD patients and 25 (10 males) healthy controls participated in this study. ASSRs were obtained using whole-head 306-channel magnetoencephalography to calculate, ASSR power values and phase locking factors (PLF). BD patients exhibited significantly reduced mean ASSR power and PLF values bilaterally at frequencies of 30, 40, and 80 Hz (p<0.05 for these frequencies). At 20 Hz, bipolar patients showed no significant reduction in mean ASSR power and PLF values. There was a significant negative correlation between 80 Hz-ASSR-power values obtained from the right hemisphere and scores on the Hamilton Depression Rating Scale (rho = -0.86, p = 0.0003). The current study showed reduced low and high gamma band ASSR power and PLF bilaterally with no significant beta band ASSR reduction in BD patients. BD patients are characterized by deficits in gamma band oscillations, which may be associated with GABA inhibitory interneuronal activity dysfunction.
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