ArticlePloS one2012
Combinatorial action of miRNAs regulates transcriptional and post-transcriptional gene silencing following in vivo PNS injury.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- How miRNAs Regulate Schwann Cells during Peripheral Nerve Regeneration-A Systemic Review.International journal of molecular sciences · 2022Pooled it
- Whole Transcriptome RNA-Seq Reveals Drivers of Pathological Dysfunction in a Transgenic Model of Alzheimer's Disease.Molecular neurobiology · 2025Article
- miR-709 exerts an angiogenic effect through a FGF2 upregulation induced by a GSK3B downregulation.Scientific reports · 2024Article
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice.Function (Oxford, England) · 2024Article
- Dedifferentiation andMolecular medicine reports · 2022Review
- Models and methods to study Schwann cells.Journal of anatomy · 2022Review
- Demethylase FTO inhibits the development of prostate cancer by upregulating EGR2 expression in an m6A manner.Turkish journal of biology = Turk biyoloji dergisi · 2022Article
- The emerging power and promise of non-coding RNAs in chronic pain.Frontiers in molecular neuroscience · 2022Review
- Crosstalk between MicroRNA and Oxidative Stress in Primary Open-Angle Glaucoma.International journal of molecular sciences · 2021Review
- Exosome-Mediated Differentiation of Mouse Embryonic Fibroblasts and Exocrine Cells into β-Like Cells and the Identification of Key miRNAs for Differentiation.Biomedicines · 2020Article
- Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress.Scientific reports · 2019Article
- Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression.Cellular and molecular life sciences : CMLS · 2019Review
- MicroRNA expression profiling in human acute organophosphorus poisoning and functional analysis of dysregulated miRNAs.African health sciences · 2018Article
- Genome expression profiling predicts the molecular mechanism of peripheral myelination.International journal of molecular medicine · 2018Article
- Egr2-dependent microRNA-138 is dispensable for peripheral nerve myelination.Scientific reports · 2018Article
- Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury.Cell reports · 2017Article
- Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA.Cell reports · 2017Article
- Identification of miRNAs involved in DRG neurite outgrowth and their putative targets.FEBS letters · 2017Article
- MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth.PLoS genetics · 2017Article
- MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions.International journal of molecular sciences · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injury response in the peripheral nervous system (PNS) is characterized by rapid alterations in the genetic program of Schwann cells. However, the epigenetic mechanisms modulating these changes remain elusive. Here we show that sciatic nerve injury in mice induces a cohort of 22 miRNAs, which coordinate Schwann cell differentiation and dedifferentiation through a combinatorial modulation of their positive and negative gene regulators. These miRNAs and their targeted mRNAs form functional complexes with the Argonaute-2 protein to mediate post-transcriptional gene silencing. MiR-138 and miR-709 show the highest affinity amongst the cohort, for binding and regulation of Egr2, Sox-2 and c-Jun expression following injury. Moreover, miR-709 participates in the formation of epigenetic silencing complexes with H3K27me3 and Argonaute-1 to induce transcriptional gene silencing of the Egr2 promoter. Collectively, we identified a discrete cohort of miRNAs as the central epigenetic regulators of the transition between differentiation and dedifferentiation during the acute phase of PNS injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.