ArticleEvidence-based complementary and alternative medicine : eCAM2012
Beneficial Effects of Ocimum gratissimum Aqueous Extract on Rats with CCl(4)-Induced Acute Liver Injury.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Aqueous Extracts ofInternational journal of molecular sciences · 2024Article
- Anti-apoptotic and antioxidant mechanisms may underlie the abrogative potential ofToxicology reports · 2024Article
- A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Heliyon · 2021Review
- Protective Effects ofInternational journal of medical sciences · 2021Article
- AqueousInternational journal of medical sciences · 2020Article
- The potential protective effect of Commelina nudiflora L. against carbon tetrachloride (CClEnvironmental health and preventive medicine · 2017Article
- Amelioration of estrogen-deficiency-induced obesity byInternational journal of medical sciences · 2017Article
- Attenuation of Oxidative Stress-Induced Cell Apoptosis in Schwann RSC96 Cells byInternational journal of medical sciences · 2017Article
- Article
- Anti-inflammatory, Anti-nociceptive and Total polyphenolic Content of Hydroethanolic Extract ofAfrican journal of medicine and medical sciences · 2014Article
- Ocimum gratissimum retards breast cancer growth and progression and is a natural inhibitor of matrix metalloproteases.Cancer biology & therapy · 2013Article
- Herbal Supplement Ameliorates Cardiac Hypertrophy in Rats with CCl(4)-Induced Liver Cirrhosis.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ocimum gratissimum (OG) is known as a food spice and traditional herb, which has been recommended for the treatment of various diseases. To investigate the hepatoprotective effect of OG aqueous extract (OGAE), male Wistar rats challenged by carbon tetrachloride (CCl(4)) were used as the animal model of chronic hepatic injury. Significantly increased serum catalase and DPPH levels were detected in CCl(4)-administrated rats that were treated with OGAE or silymarin as compared to those rats that were treated with saline or CCl(4). In contrast, significantly decreased stress proteins including HSP70 and iNOS were observed in livers of CCl(4)-administrated rats that were treated with OGAE or sylimarin as compared to those rats that were treated with saline or CCl(4). Moreover, significant decreases of MMP-9/MMP-2 ratio, uPA, phosphorylated ERK (p-ERK) and NF-κB (p-P65) were detected in livers of CCl(4)-administrated rats that were treated with OGAE or sylimarin as compared to those rats that were treated with saline or CCl(4). These findings imply that OGAE can efficiently inhibit CCl(4)-induced liver injuries in rats and may therefore be a potential food or herb for preventing liver injuries.
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Registered trials
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