ArticleCerebral cortex (New York, N.Y. : 1991)2013
FoxP2 is a parvocellular-specific transcription factor in the visual thalamus of monkeys and ferrets.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 72 citations in OpenAlex.
- Comparative analysis of Foxp2 expression in the thalamus of mice, rats, and macaques: implications for the evolution of language circuits.Brain structure & function · 2026Article
- Investigation of the mechanisms underlying the development and evolution of the mammalian cerebrum using gyrencephalic ferrets.Frontiers in cell and developmental biology · 2026Review
- Article
- Evolutionary changes leading to efficient glymphatic circulation in the mammalian brain.Nature communications · 2024Article
- Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment.bioRxiv : the preprint server for biology · 2024Article
- Visual cortex damage in a ferret model of ocular hypertension.Japanese journal of ophthalmology · 2022Article
- Investigation of the Mechanisms Underlying the Development and Evolution of the Cerebral Cortex Using Gyrencephalic Ferrets.Frontiers in cell and developmental biology · 2022Review
- Article
- BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex.Scientific reports · 2021Article
- Glial cell type-specific gene expression in the mouse cerebrum using the piggyBac system and in utero electroporation.Scientific reports · 2021Article
- Role of Feedback Connections in Central Visual Processing.Annual review of vision science · 2020Review
- A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain.eLife · 2020Article
- The origin and development of subcortical U-fibers in gyrencephalic ferrets.Molecular brain · 2020Article
- Structural Changes and Astrocyte Response of the Lateral Geniculate Nucleus in a Ferret Model of Ocular Hypertension.International journal of molecular sciences · 2020Article
- Visualization of the Retina in Intact Eyes of Mice and Ferrets Using a Tissue Clearing Method.Translational vision science & technology · 2020Article
- FGF Signaling Directs the Cell Fate Switch from Neurons to Astrocytes in the Developing Mouse Cerebral Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.BMC neuroscience · 2018Article
- Distribution and Morphological Features of Microglia in the Developing Cerebral Cortex of Gyrencephalic Mammals.Neurochemical research · 2018Article
- Article
- Molecular investigations of development and diseases of the brain of higher mammals using the ferret.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
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Abstract
Although the parallel visual pathways are a fundamental basis of visual processing, our knowledge of their molecular properties is still limited. Here, we uncovered a parvocellular-specific molecule in the dorsal lateral geniculate nucleus (dLGN) of higher mammals. We found that FoxP2 transcription factor was specifically expressed in X cells of the adult ferret dLGN. Interestingly, FoxP2 was also specifically expressed in parvocellular layers 3-6 of the dLGN of adult old world monkeys, providing new evidence for a homology between X cells in the ferret dLGN and parvocellular cells in the monkey dLGN. Furthermore, this expression pattern was established as early as gestation day 140 in the embryonic monkey dLGN, suggesting that parvocellular specification has already occurred when the cytoarchitectonic dLGN layers are formed. Our results should help in gaining a fundamental understanding of the development, evolution, and function of the parallel visual pathways, which are especially prominent in higher mammals.
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