ArticleThe Journal of comparative neurology2013
Development of the principal nucleus trigeminal lemniscal projections in the mouse.
Article in The Journal of comparative neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Trigeminal nociceptive somatotopy across brainstem and cortex and their functional interactions.The journal of headache and pain · 2026Article
- Trigeminal Nerve and Vestibular System: Update on Pathophysiological and Clinical Links.Audiology research · 2025Review
- External trigeminal nerve stimulation for neuropsychiatric disorders: mechanisms, efficacy, and future directions.Frontiers in neurology · 2025Review
- Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System.Biomedicines · 2023Review
- Article
- Somatotopy of Mouse Spinothalamic Innervation and the Localization of a Noxious Stimulus Requires Deleted in Colorectal Carcinoma Expression by Phox2a Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Ex vivo visualization of the trigeminal pathways in the human brainstem using 11.7T diffusion MRI combined with microscopy polarized light imaging.Brain structure & function · 2019Article
- Development of tactile sensory circuits in the CNS.Current opinion in neurobiology · 2018Review
- Functional Topography and Development of Inhibitory Reticulothalamic Barreloid Projections.Frontiers in neuroanatomy · 2018Article
- Impact of thalamocortical input on barrel cortex development.Neuroscience · 2018Review
- A mutant with bilateral whisker to barrel inputs unveils somatosensory mapping rules in the cerebral cortex.eLife · 2017Article
- Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Development and critical period plasticity of the barrel cortex.The European journal of neuroscience · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The principal sensory (PrV) nucleus-based trigeminal lemniscus conveys whisker-specific neural patterns to the ventroposteromedial (VPM) nucleus of the thalamus and subsequently to the primary somatosensory cortex. Here we examined the perinatal development of this pathway with carbocyanine dye labeling in embryonic and early postnatal mouse brains. We developed a novel preparation in which the embryonic hindbrain and the diencephalon are flattened out, allowing a birds-eye view of the PrV lemniscus in its entirety. For postnatal brains we used another novel approach by sectioning the brain along an empirically determined oblique horizontal angle, again preserving the trigeminothalamic pathway. PrV neurons are born along the hindbrain ventricular zone and migrate radially for a short distance to coalesce into a nucleus adjacent to the ascending trigeminal tract. During migration of the spindle-shaped cell bodies, slender axonal processes grow along the opposite direction towards the floor plate. As early as embryonic day (E) 11, pioneering axons tipped with large growth cones cross the ventral midline and immediately make a right angle turn. By E13 many PrV axons form fascicles crossing the midline and follow a rostral course. PrV axons reach the midbrain by E15 and the thalamus by E17. While the target recognition and invasion occurs prenatally, organization of PrV axon terminals into whisker-specific rows and patches takes place during the first 4 postnatal (P) days. Initially diffuse and exuberant projections in the VPM at P1 coalesce into row and whisker specific terminal zones by P4.
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