ArticleJournal of the American Society for Mass Spectrometry2012
A mechanism for ionization of nonvolatile compounds in mass spectrometry: considerations from MALDI and inlet ionization.
Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Multi-Port Vacuum Assembly Device Designed for Simplified Point-of-Need Chemical and Biological Analyses Using Mass Spectrometry.Analytical chemistry · 2026Article
- Effects of Inlet Capillary Temperature in Atmospheric-Pressure Infrared Laser-Ablation Plasma Postionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2025Article
- The Role of Aerosol Liquid Water in Droplet-Assisted Ionization Mass Spectrometry.Analytical chemistry · 2025Article
- New Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art.Journal of the American Society for Mass Spectrometry · 2024Review
- Direct sub-atmospheric pressure ionization mass spectrometry: Evaporation/sublimation-driven ionization is amazing, fundamentally, and practically.Journal of mass spectrometry : JMS · 2024Review
- Instrumentation development, improvement, simplification, and miniaturization: The multifunctional plate source for use in mass spectrometry.European journal of mass spectrometry (Chichester, England) · 2023Article
- Toward a molecular understanding of the surface composition of atmospherically relevant organic particles.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dual roles of [CHCA + Na/K/Cs]Rapid communications in mass spectrometry : RCM · 2021Article
- Astrochemical Pathways to Complex Organic and Prebiotic Molecules: Experimental Perspectives for In Situ Solid-State Studies.Life (Basel, Switzerland) · 2021Review
- Production and analysis of multiply charged negative ions by liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry.Rapid communications in mass spectrometry : RCM · 2021Article
- Fundamental Studies of New Ionization Technologies and Insights from IMS-MS.Journal of the American Society for Mass Spectrometry · 2019Article
- Characterizing and alleviating ion suppression effects in atmospheric pressure matrix-assisted laser desorption/ionization.Rapid communications in mass spectrometry : RCM · 2019Article
- Biomolecular Clusters Distribution up to Mega Dalton Region Using MALDI-Quadrupole Ion Trap Mass Spectrometer.International journal of molecular sciences · 2018Article
- New insights into mechanisms of material ejection in MALDI mass spectrometry for a wide range of spot sizes.Scientific reports · 2018Article
- A high resolution atmospheric pressure matrix-assisted laser desorption/ionization-quadrupole-orbitrap MS platform enables in situ analysis of biomolecules by multi-mode ionization and acquisition.Analytica chimica acta · 2018Article
- Spontaneous Charge Separation and Sublimation Processes are Ubiquitous in Nature and in Ionization Processes in Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2018Article
- Rapid high mass resolution mass spectrometry using matrix-assisted ionization.Methods (San Diego, Calif.) · 2016Article
- "Magic" Ionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Matrix-Assisted Ionization-Ion Mobility Spectrometry-Mass Spectrometry: Selective Analysis of a Europium-PEG Complex in a Crude Mixture.Journal of the American Society for Mass Spectrometry · 2015Article
- Improving the Sensitivity of Matrix-Assisted Ionization (MAI) Mass Spectrometry Using Ammonium Salts.Journal of the American Society for Mass Spectrometry · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanistic arguments relative to matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) address observations that predominately singly charged ions are detected. However, recently a matrix assisted laser ablation method, laserspray ionization (LSI), was introduced that can use the same sample preparation and laser as MALDI, but produce highly charged ions from proteins. In MALDI, ions are generated from neutral molecules by the photon energy provided to a matrix, while in LSI ions are produced inside a heated inlet tube linking atmospheric pressure and the first vacuum region of the mass spectrometer. Some LSI matrices also produce highly charged ions with MALDI ion sources operated at intermediate pressure or high vacuum. The operational similarity of LSI to MALDI, and the large difference in charge states observed by these methods, provides information of fundamental importance to proposed ionization mechanisms for LSI and MALDI. Here, we present data suggesting that the prompt and delayed ionization reported for vacuum MALDI are both fast processes relative to producing highly charged ions by LSI. The energy supplied to produce these charged clusters/droplets as well as their size and time available for desolvation are determining factors in the charge states of the ions observed. Further, charged droplets/clusters may be a common link for ionization of nonvolatile compounds by a variety of MS ionization methods, including MALDI and LSI.
Identifiers
22791582What OpenQuestion holds
Registered trials
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