ArticleIndian journal of pediatrics2013
Prevalence of celiac disease in Indian children with Down syndrome and its clinical and laboratory predictors.
Article in Indian journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Pooled it
- Prevalence of celiac disease in low and high risk population in Asia-Pacific region: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Assessment of Knowledge of Celiac Disease and Associated Conditions Among Dietitians in Jordan.International journal of environmental research and public health · 2025Article
- Incidence of Celiac Disease in Down Syndrome: A Longitudinal, Population-Based Birth Cohort Study.Clinical pediatrics · 2020Article
- Celiac disease: What the Indian pediatricians know about the disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- Article
- Assessment of coeliac disease prevalence in patients with Down syndrome in Poland - a multi-centre study.Przeglad gastroenterologiczny · 2016Article
- The celiac iceberg: from the clinical spectrum to serology and histopathology in children and adolescents with type 1 diabetes mellitus and Down syndrome.Scandinavian journal of gastroenterology · 2016Article
- Recurrent abdominal pain in a patient with Down syndrome.Digestive diseases and sciences · 2015Article
- Diagnosis and management of Down syndrome.Indian journal of pediatrics · 2014Article
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the prevalence of celiac disease in Indian children with Down syndrome and evaluate its clinical and laboratory predictors.
methodsPrevalence of celiac disease (CD) was assessed in 100 patients with Down syndrome (DS) attending pediatric genetic clinic at All India Institute of Medical Sciences,in a prospective observational study, based on the characteristic symptomatology, positive indirect immunofluorescence anti endomyseal antibody(anti EMA) test and duodenal histology based on adapted Marsh criteria. Clinical and laboratory features were compared in children having both CD and DS and those with DS alone.
resultsAnti EMA was positive in 7 out of 100 patients screened for CD; 6 in whom the duodenal biopsy could be done showed histopathological features consistent with celiac disease. Amongst various clinical features evaluated as possible risk factors; pallor reached statistical significance (OR = 7.04 95%CI 1.08-45.7). In addition anemia (Hb <11 g%) was significantly associated with CD (p = 0.06).
conclusionsThe present results showed a high prevalence of CD in DS children in a tertiary hospital in India and low hemoglobin to be an important risk factor. The authors recommend that all Indian children with Down syndrome, particularly those with anemia should be screened for celiac disease.
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