ArticleEuropean journal of heart failure2012
Association of QRS duration with left ventricular structure and function and risk of heart failure in middle-aged and older adults: the Multi-Ethnic Study of Atherosclerosis (MESA).
Article in European journal of heart failure, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
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- ECG features improve multimodal deep learning prediction of incident T2DM in a Middle Eastern cohort.Scientific reports · 2025Article
- Large Language Model-informed ECG Dual Attention Network for Heart Failure Risk Prediction.IEEE transactions on big data · 2025Article
- Screening Tool for Paroxysmal Atrial Fibrillation Based on a Deep-Learning Algorithm Using Printed 12-Lead Electrocardiographic Records during Sinus Rhythm.Reviews in cardiovascular medicine · 2024Article
- An association between heart rate variability and incident heart failure in an elderly cohort.Clinical cardiology · 2024Article
- Preventing new-onset heart failure: Intervening at stage A.American journal of preventive cardiology · 2023Review
- Development, External Validation, and Visualization of Machine Learning Models for Predicting Occurrence of Acute Kidney Injury after Cardiac Surgery.Reviews in cardiovascular medicine · 2023Article
- SCOPE: predicting future diagnoses in office visits using electronic health records.Scientific reports · 2023Article
- Clinical applicability of an artificial intelligence prediction algorithm for early prediction of non-persistent atrial fibrillation.Frontiers in cardiovascular medicine · 2023Article
- Subtle QRS changes are associated with reduced ejection fraction, diastolic dysfunction, and heart failure development and therapy responsiveness: Applications for artificial intelligence to ECG.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022Review
- Delayed intrinsicoid deflection: Electrocardiographic harbinger of heart disease.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022Review
- Observational
- ECG-AI: electrocardiographic artificial intelligence model for prediction of heart failure.European heart journal. Digital health · 2021Article
- Adult height and incidence of atrial fibrillation and heart failure in older men: The British Regional Heart Study.International journal of cardiology. Heart & vasculature · 2021Article
- Beat-to-beat blood pressure variability in patients with obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- T-wave and its association with myocardial fibrosis on cardiovascular magnetic resonance examination.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021Article
- Left Ventricular Remodeling and Myocardial Work: Results From the Population-Based STAAB Cohort Study.Frontiers in cardiovascular medicine · 2021Article
- Prolonged QRS independently predicts long-term all-cause mortality in patients with narrow QRS complex undergoing coronary artery bypass grafting surgery (9-year follow-up results).Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2020Article
- Refocusing on the Primary Prevention of Heart Failure.Current treatment options in cardiovascular medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
aimsProlonged QRS duration (QRSd) on the electrocardiogram (ECG) has been associated with cardiac structural and functional abnormalities by echocardiography and an increased risk of heart failure (HF). Data are sparse on these relationships in middle-aged and elderly individuals free of baseline cardiovascular disease with respect to cardiac magnetic resonance imaging (MRI). We sought to determine whether QRSd is associated with incident HF and measures of cardiac structure and function by cardiac MRI. METHODS AND
resultsWe analysed baseline ECGs in the Multi-Ethnic Study of Atherosclerosis (MESA) to determine whether QRSd >100 ms was associated with incident HF. We adjusted for demographic and clinical risk factors, as well as MRI measures of left ventricular (LV) structure and function. Among 4591 eligible participants (51% women; 39% white; mean age 61 years), 75 developed incident HF over a mean follow-up of 7.1 years. QRSd >100 ms was significantly associated with MRI measures of cardiac structure and function, as well as incident HF, even after adjustment for demographic covariates [hazard ratio (HR) 2.10, 95% confidence interval (CI) 1.29-3.42; P = 0.003] and clinical risk factors (HR 1.86, 95% CI 1.14-3.03; P = 0.01). With further adjustment for individual LV structural measures, findings were attenuated to non-significance. Separate adjustment for LV functional measures yielded only mild attenuation.
conclusionIn middle-aged and older adults without cardiovascular disease, a QRSd >100 ms was significantly associated with incident HF. After adjustment for LV structural measures, the association was attenuated to non-significance, suggesting that prolonged QRSd is potentially a useful marker of LV structure that may predispose to HF risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.