ArticleEuropean journal of nuclear medicine and molecular imaging2012
Reproducibility of planar (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in patients with heart failure.
Article in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed.
- Relationship of left ventricular global longitudinal strain with cardiac autonomic denervation as assessed byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Trial
- Impact of an exercise training program on cardiac neuronal function in heart failure patients on optimal medical therapy : A randomized Iodine-123 metaiodobenzylguanidine scintigraphy study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Trial
- Value of multi-parameterEJNMMI research · 2025Article
- Cardiac 123I-Metaiodobenzylguanidine (MIBG) Scintigraphy in Parkinson's Disease: A Comprehensive Review.Brain sciences · 2023Review
- Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Comparison of Taiwanese and European Calibration Factors for Heart-to-Mediastinum Ratio in MulticenterAnnals of nuclear cardiology · 2023Article
- A New Deep Learning Method with Self-Supervised Learning for Delineation of the Electrocardiogram.Entropy (Basel, Switzerland) · 2022Article
- Serial changes in cardiac sympathetic nervous function after transcatheter aortic valve replacement: A prospective observational study usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Observational
- Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson's disease.Frontiers in medicine · 2022Article
- TheJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Quality and utility of [Annals of nuclear medicine · 2021Article
- How to best appreciate the possible clinical role of cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Cardio-pulmonary involvement in pulmonary arterial hypertension: A perfusion and innervation scintigraphic evaluation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity.Scientific reports · 2020Article
- Early effects of transcatheter aortic valve replacement on cardiac sympathetic nervous function assessed byEuropean journal of nuclear medicine and molecular imaging · 2020Observational
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Reliability of theJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Role of cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Observational
- IsAnnals of nuclear medicine · 2018Article
- Influence of ROI definition on the heart-to-mediastinum ratio in planarJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
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8 authors.
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Abstract
purposeDespite its high prognostic value, widespread clinical implementation of (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is hampered by a lack of validation and standardization. The purpose of this study was to assess the reliability of planar (123)I-MIBG myocardial scintigraphy in patients with heart failure (HF).
methodsPlanar myocardial MIBG images of 70 HF patients were analysed by two experienced and one inexperienced observer. The reproducibility of early and delayed heart-to-mediastinum (H/M) ratios, as well as washout rate (WR) calculated by two different methods, was assessed using the intraclass correlation coefficient (ICC) and the Bland-Altman analysis. In addition, a subanalysis in patients with a very low H/M ratio (delayed H/M ratio <1.4) was performed. The delayed H/M ratio was also assessed using fixed-size oval and circular cardiac regions of interest (ROI).
resultsIntra- and interobserver analyses and experienced versus inexperienced observer analysis showed excellent agreement for the measured early and delayed H/M ratios and WR on planar (123)I-MIBG images (the ICCs for the delayed H/M ratios were 0.98, 0.96 and 0.90, respectively). In addition, the WR without background correction resulted in higher reliability than the WR with background correction (the interobserver Bland-Altman 95 % limits of agreement were -2.50 to 2.16 and -10.10 to 10.14, respectively). Furthermore, the delayed H/M ratio measurements remained reliable in a subgroup of patients with a very low delayed H/M ratio (ICC 0.93 for the inter-observer analysis). Moreover, a fixed-size cardiac ROI could be used for the assessment of delayed H/M ratios, with good reliability of the measurement.
conclusionThe present study showed a high reliability of planar (123)I-MIBG myocardial scintigraphy in HF patients, confirming that MIBG myocardial scintigraphy can be implemented easily for clinical risk stratification in HF.
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