ArticleSmall GTPases
The circumferential actomyosin belt in epithelial cells is regulated by the Lulu2-p114RhoGEF system.
Article in Small GTPases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Transcriptomic Context ofBiomedicines · 2023Article
- The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction duringMolecular biology of the cell · 2023Article
- Lmo7 recruits myosin II heavy chain to regulate actomyosin contractility and apical domain size in Xenopus ectoderm.Development (Cambridge, England) · 2022Article
- MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block?Tissue barriers · 2021Review
- Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex.eLife · 2021Article
- Article
- Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly.The Journal of cell biology · 2019Article
- Oligomerization of the FERM-FA protein Yurt controls epithelial cell polarity.The Journal of cell biology · 2018Article
- Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity.Nature communications · 2017Article
- Remodeling the zonula adherens in response to tension and the role of afadin in this response.The Journal of cell biology · 2016Article
- CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.Molecular and cellular biology · 2015Article
- RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.The international journal of biochemistry & cell biology · 2015Review
- GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure.Journal of cell science · 2014Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In epithelial cells, myosin-II-dependent forces regulate many aspects of animal morphogenesis, such as apical constriction, cell intercalation, cell sorting, and the formation and maintenance of the adherens junction. These forces are mainly generated by the circumferential actomyosin belt, which is composed of F-actin-myosin II bundles located along apical cell-cell junctions. Although several of the molecular pathways regulating the belt have been identified, the precise mechanisms underlying its function are largely unknown. Our recent studies identified Lulu proteins (Lulu1 and Lulu2), FERM-domain-containing molecules, as the regulators of the belt. Lulus activate the circumferential actomyosin belt and thereby induce apical constriction in epithelial cells; conversely, RNAi-mediated Lulu-knockdown results in the severe disorganization of the circumferential actomyosin belt. We also showed that p114RhoGEF is a downstream molecule of Lulu2 in its regulation of the belt; Lulu2 enhances the catalytic activity of p114RhoGEF through a direct interaction and thereby activates the circumferential actomyosin belt. We further identified aPKC and Patj as regulators of Lulu2-p114RhoGEF. In this commentary, we discuss current knowledge of the circumferential actomyosin belt's regulation, focusing on the Lulu2-p114RhoGEF system.
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