ReviewBrain research2012
Brain connexins in demyelinating diseases: therapeutic potential of glial targets.
Review in Brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering.Biological research · 2024Article
- Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model.Scientific reports · 2024Article
- Astrocytes as Context for the Involvement of Myelin and Nodes of Ranvier in the Pathophysiology of Depression and Stress-Related Disorders.Journal of psychiatry and brain science · 2023Article
- Article
- Location Matters: Navigating Regional Heterogeneity of the Neurovascular Unit.Frontiers in cellular neuroscience · 2021Review
- Heterogeneity of Astrocytes in Grey and White Matter.Neurochemical research · 2021Review
- Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease.Frontiers in cellular neuroscience · 2019Review
- Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.Theranostics · 2019Article
- An in vitro model for studying CNS white matter: functional properties and experimental approaches.F1000Research · 2019Article
- Inhibition of Astrocyte Connexin 43 Channels Facilitates the Differentiation of Oligodendrocyte Precursor Cells Under Hypoxic Conditions In Vitro.Journal of molecular neuroscience : MN · 2018Article
- Gap junction channels as potential targets for the treatment of major depressive disorder.Psychopharmacology · 2018Review
- Single-cell Microinjection for Cell Communication Analysis.Journal of visualized experiments : JoVE · 2017Article
- Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models.Current neuropharmacology · 2016Review
- Connexin Type and Fluorescent Protein Fusion Tag Determine Structural Stability of Gap Junction Plaques.The Journal of biological chemistry · 2015Article
- Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury.World journal of stem cells · 2015Review
- Antidepressants Impact Connexin 43 Channel Functions in Astrocytes.Frontiers in cellular neuroscience · 2015Article
- Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression.Journal of psychiatric research · 2014Article
- Connexins-mediated glia networking impacts myelination and remyelination in the central nervous system.Molecular neurobiology · 2014Review
- Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues.FEBS letters · 2014Review
- Central myelin gene expression during postnatal development in rats exposed to nicotine gestationally.Neuroscience letters · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Several demyelinating syndromes have been linked to mutations in glial gap junction proteins, the connexins. Although mutations in connexins of the myelinating cells, Schwann cells and oligodendrocytes, were initially described, recent data have shown that astrocytes also play a major role in the demyelination process. Alterations in astrocytic proteins directly affect the oligodendrocytes' ability to maintain myelin structure, and associated astrocytic proteins that regulate water and ionic fluxes, including aquaporins, can also regulate myelin integrity. Here, we will review the main evidence from human disorders and transgenic mouse models that implicate glial gap junction proteins in demyelinating diseases and the therapeutic potential of some of these targets. This article is part of a Special Issue entitled Electrical Synapses.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.