Evidence map›Paper›PMID 22789743›Full record

ReviewCurrent opinion in virology2012

Rotavirus non-structural proteins: structure and function.

Liya Hu, Sue E Crawford, Joseph M Hyser, Mary K Estes, B V Venkataram Prasad

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 88 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Intercellular Transport of Viral Proteins.Results and problems in cell differentiation · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Genome Sequence of Rotavirus A from a Florida Racing Pigeon (Microbiology resource announcements · 2022
    Article
  16. Structural basis of rotavirus RNA chaperone displacement and RNA annealing.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Liya HuVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, United States.
Sue E Crawford
Joseph M Hyser
Mary K Estes
B V Venkataram Prasad
Baylor College of Medicine · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Structural Studies on RotavirusesR37AI036040 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI PRASAD, BIDADI VENKATARAM · 2003 to 2022
$10.9M
Regulation of Rotavirus ReplicationR01AI080656 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Sue Ellen Crawford, Mary Kolb Estes · 2009 to 2026
$7.9M
STRUCTURAL STUDIES ON ROTAVIRUSESR01AI036040 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Bidadi Venkataram Prasad · 1994 to 2026
$4.3M
Regulation of Rotavirus ReplicationR56AI080656 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI ESTES, MARY KOLB · 2014 to 2014
$433k
NIAID NIH HHS AI 080656NIAID NIH HHS AI36040NIAID NIH HHS R01 AI036040NIAID NIH HHS R01 AI080656NIAID NIH HHS R37 AI036040NIAID NIH HHS R56 AI080656NIDDK NIH HHS P30 DK056338NIDDK NIH HHS P30 DK56338
6 · The paper itself

Abstract

The replication of rotavirus is a complex process that is orchestrated by an exquisite interplay between the rotavirus non-structural and structural proteins. Subsequent to particle entry and genome transcription, the non-structural proteins coordinate and regulate viral mRNA translation and the formation of electron-dense viroplasms that serve as exclusive compartments for genome replication, genome encapsidation and capsid assembly. In addition, non-structural proteins are involved in antagonizing the antiviral host response and in subverting important cellular processes to enable successful virus replication. Although far from complete, new structural studies, together with functional studies, provide substantial insight into how the non-structural proteins coordinate rotavirus replication. This brief review highlights our current knowledge of the structure-function relationships of the rotavirus non-structural proteins, as well as fascinating questions that remain to be understood.

Indexed as

AnimalsHumansRotavirusRotavirus InfectionsViral Nonstructural ProteinsViral Nonstructural Proteins

Identifiers

PMID22789743
PMCPMC3422752
OpenAlexW2047930958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.