ReviewHuman immunology2012
Alloantibody induced platelet responses in transplants: potent mediators in small packages.
Review in Human immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Transplant renal artery thrombosis caused by acute rejection : a case report.BMC nephrology · 2026Article
- Balancing B cell responses to the allograft: implications for vaccination.Frontiers in immunology · 2022Review
- B Cell Immunity in Lung Transplant Rejection - Effector Mechanisms and Therapeutic Implications.Frontiers in immunology · 2022Review
- Antibody-mediated rejection after lung transplantation.Annals of translational medicine · 2020Review
- Mechanisms of antibody-mediated acute and chronic rejection of kidney allografts.Current opinion in organ transplantation · 2016Review
- CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction.Journal of immunology research · 2016Article
- Platelets in early antibody-mediated rejection of renal transplants.Journal of the American Society of Nephrology : JASN · 2015Article
- Rational clinical trial design for antibody mediated renal allograft injury.Frontiers in bioscience (Landmark edition) · 2015Review
- Role of anti-vimentin antibodies in allograft rejection.Human immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The early histological studies of organ allografts noted platelets attached to vascular endothelium. Platelets adhere to vessels before any morphological evidence of endothelial injury. Subsequently, in vitro and in vivo experiments have demonstrated that alloantibodies can induce exocytosis of von Willebrand factor and P-selectin from endothelial cells and attachment of platelets within minutes. Platelets also adhere to and stimulate leukocytes. These interactions are increased by complement activation. After attachment platelets degranulate, releasing preformed mediators. Some chemokines stored together in platelet granules can form heteromers with synergistic functions. Heteromers containing platelet factor 4 (PF4; CXCL4) are specific to platelets and provide insights to unique platelet functions and opportunities for therapeutic intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.