Evidence map›Paper›PMID 22789450›Full record

ArticleNursing outlook

Using meta-analyses for comparative effectiveness research.

Vicki S Conn, Todd M Ruppar, Lorraine J Phillips, Jo-Ana D Chase

Abstract read
In one paragraph

Article in Nursing outlook. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vicki S ConnMeta-Analysis Research Center, School of Nursing, University of Missouri, Columbia, MO 65211, USA. conn@missouri.edu
Todd M Ruppar
Lorraine J Phillips
Jo-Ana D Chase

Funding

Meta-Analysis of Interventions to Improve Medication AdherenceR01NR011990 · NINR · UNIVERSITY OF MISSOURI-COLUMBIA · PI CONN, VICKI S · 2010 to 2013
$1.7M
Meta-Analysis of Interventions to Increase Exercise/Physical AcivityR01NR009656 · NINR · UNIVERSITY OF MISSOURI-COLUMBIA · PI CONN, VICKI S · 2006 to 2009
$1.6M
NINR NIH HHS R01 NR009656NINR NIH HHS R01NR009656NINR NIH HHS R01 NR011990NINR NIH HHS R01NR011990
6 · The paper itself

Abstract

Comparative effectiveness research seeks to identify the most effective interventions for particular patient populations. Meta-analysis is an especially valuable form of comparative effectiveness research because it emphasizes the magnitude of intervention effects rather than relying on tests of statistical significance among primary studies. Overall effects can be calculated for diverse clinical and patient-centered variables to determine the outcome patterns. Moderator analyses compare intervention characteristics among primary studies by determining whether effect sizes vary among studies with different intervention characteristics. Intervention effectiveness can be linked to patient characteristics to provide evidence for patient-centered care. Moderator analyses often answer questions never posed by primary studies because neither multiple intervention characteristics nor populations are compared in single primary studies. Thus, meta-analyses provide unique contributions to knowledge. Although meta-analysis is a powerful comparative effectiveness strategy, methodological challenges and limitations in primary research must be acknowledged to interpret findings.

Indexed as

Meta-Analysis as TopicResearch DesignComparative Effectiveness ResearchHumansNursing Research

Identifiers

PMID22789450
PMCPMC3396882

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.