ArticleThe Journal of allergy and clinical immunology2012
Infant origins of childhood asthma associated with specific molds.
Article in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 208 citations in OpenAlex.
- Association of indoor microbial aerosols with respiratory symptoms among under-five children: a systematic review and meta-analysis.Environmental health : a global access science source · 2021Pooled it
- A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years.BMJ open · 2014Pooled it
- Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Domestic fungal exposure and asthma morbidity in New York City children following Superstorm Sandy.Journal of exposure science & environmental epidemiology · 2026Article
- Individual and combined effects of indoor home exposures and ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026Article
- Residential factors associated with mental health in United States Veterans, Air Force military, and Air Force employees.Indoor environments · 2025Article
- Moving beyond species: fungal function in house dust provides novel targets for potential indicators of mold growth in homes.Microbiome · 2024Article
- The spectrum of environmental disparities in asthma.The Journal of allergy and clinical immunology · 2024Article
- Association of exposure to indoor molds and dampness with allergic diseases at water-damaged dwellings in Korea.Scientific reports · 2024Article
- AWMF mold guideline "Medical clinical diagnostics for indoor mold exposure" - Update 2023 AWMF Register No. 161/001.Allergologie select · 2024Article
- A one health roadmap towards understanding and mitigating emerging Fungal Antimicrobial Resistance: fAMR.npj antimicrobials and resistance · 2024Review
- Indoor Bacterial and Fungal Burden in "Moldy" versus "Non-Moldy" Homes: A Case Study Employing Advanced Sequencing Techniques in a US Metropolitan Area.Pathogens (Basel, Switzerland) · 2023Article
- Establishment of an artificial particulate matter-induced lung disease model through analyzing pathological changes and transcriptomic profiles in mice.Scientific reports · 2023Article
- HEPA filtration intervention in classrooms may improve some students' asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Season, Vegetation Proximity and Building Age Shape the Indoor Fungal Communities' Composition at City-Scale.Journal of fungi (Basel, Switzerland) · 2022Article
- Environmental Factors Shaping the Diversity and Spatial-Temporal Distribution of Indoor and Outdoor Culturable Airborne Fungal Communities in Tianjin University Campus, Tianjin, China.Frontiers in microbiology · 2022Article
- Housing and asthma disparities.The Journal of allergy and clinical immunology · 2021Article
- Innate Type 2 Response toJournal of Korean medical science · 2021Article
- Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide.Respiratory research · 2021Article
- Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case-control study.BMC pulmonary medicine · 2021Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe specific cause or causes of asthma development must be identified to prevent this disease.
objectiveOur hypothesis was that specific mold exposures are associated with childhood asthma development.
methodsInfants were identified from birth certificates. Dust samples were collected from 289 homes when the infants were 8 months of age. Samples were analyzed for concentrations of 36 molds that comprise the Environmental Relative Moldiness Index (ERMI) and endotoxin, house dust mite, cat, dog, and cockroach allergens. Children were evaluated at age 7 years for asthma based on reported symptoms and objective measures of lung function. Host, environmental exposure, and home characteristics evaluated included a history of parental asthma, race, sex, upper and lower respiratory tract symptoms, season of birth, family income, cigarette smoke exposure, air conditioning, use of a dehumidifier, presence of carpeting, age of home, and visible mold at age 1 year and child's positive skin prick test response to aeroallergens and molds at age 7 years.
resultsAsthma was diagnosed in 24% of the children at age 7 years. A statistically significant increase in asthma risk at age 7 years was associated with high ERMI values in the child's home in infancy (adjusted relative risk for a 10-unit increase in ERMI value, 1.8; 95% CI, 1.5-2.2). The summation of levels of 3 mold species, Aspergillus ochraceus, Aspergillus unguis, and Penicillium variabile, was significantly associated with asthma (adjusted relative risk, 2.2; 95% CI, 1.8-2.7).
conclusionIn this birth cohort study exposure during infancy to 3 mold species common to water-damaged buildings was associated with childhood asthma at age 7 years.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.