ArticleCritical care (London, England)2012
The impact of statin use on pneumonia risk and outcome: a combined population-based case-control and cohort study.
Article in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis.PloS one · 2015Pooled it
- Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality.PloS one · 2012Pooled it
- Combining Geriatric Nutritional Risk Index with Total Cholesterol to Predict Pneumonia Mortality Risks in a Cohort of General Older Adults.Nutrients · 2026Article
- Impact of Long-Term Statin Therapy on Incidence and Severity of Community-Acquired Pneumonia: A Real-World Data Analysis.Biomedicines · 2025Article
- Unveiling the Antibacterial Properties of Statins: AnAdvances in pharmacological and pharmaceutical sciences · 2024Article
- How Long After Coronary Artery Bypass Surgery Can Patients Have Elective Safer Non-Cardiac Surgery?Journal of multidisciplinary healthcare · 2024Article
- Acetylsalicylic acid use is associated with improved survival in bacteremic pneumococcal pneumonia: A long-term nationwide study.Journal of internal medicine · 2022Article
- Exploring the Genetic Associations Between the Use of Statins and Alzheimer's Disease.Journal of lipid and atherosclerosis · 2022Article
- Triggering of cardiovascular disease by infection type: The Atherosclerosis Risk in Communities study (ARIC).International journal of cardiology · 2021Article
- Statin Use Is Associated with Decreased Risk of Invasive Mechanical Ventilation in COVID-19 Patients: A Preliminary Study.Pathogens (Basel, Switzerland) · 2020Article
- Granulocyte-targeted therapies for airway diseases.Pharmacological research · 2020Review
- Protective Capacity of Statins during Pneumonia Is Dependent on Etiological Agent and Obesity.Frontiers in cellular and infection microbiology · 2018Article
- The Use of Statins and Risk of Community-Acquired Pneumonia.Current infectious disease reports · 2017Review
- Statin Use and Hospital Length of Stay Among Adults Hospitalized With Community-acquired Pneumonia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Impact of Statins on Influenza Vaccine Effectiveness Against Medically Attended Acute Respiratory Illness.The Journal of infectious diseases · 2016Article
- Mortality benefit of statin use in traumatic spinal cord injury: a retrospective analysis.Spinal cord · 2016Observational
- Statin use associated with a reduced risk of pneumonia requiring hospitalization in patients with myocardial infarction: a nested case-control study.BMC cardiovascular disorders · 2016 · on this mapObservational
- Article
- Pre-existing atrial fibrillation and risk of arterial thromboembolism and death following pneumonia: a population-based cohort study.BMJ open · 2014Article
- Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target.eLife · 2014Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe impact of statin use on pneumonia risk and outcome remains unclear. We therefore examined this risk in a population-based case-control study and did a 5-year update of our previous 30-day mortality analyses.
methodsWe identified 70,953 adults with a first-time hospitalization for pneumonia between 1997 and 2009 in Northern Denmark. Ten age- and sex-matched population controls were selected for each pneumonia patient. To control for potential confounders, we retrieved individual-level data on other medications, comorbidities, recent surgery, socioeconomic indicators, influenza vaccination, and other markers of frailty or health awareness from medical databases. We followed all pneumonia patients for 30 days after hospital admission.
resultsA total of 7,223 pneumonia cases (10.2%) and 64,523 controls (9.1%) were statin users before admission, corresponding to an age- and sex-matched odds ratio (OR) of 1.17 (95% confidence interval [CI]: 1.14-1.21). After controlling for higher comorbidity and a wide range of other potential confounders, the adjusted OR for pneumonia associated with current statin use dropped to 0.80 (95% CI: 0.77-0.83). Previous statin use was not associated with decreased pneumonia risk (adjusted OR = 0.97, 95% CI: 0.91-1.02). Decreased risk remained significant after further adjustment for frailty and health awareness markers.
conclusionsCurrent statin use was associated with both a decreased risk of hospitalization for pneumonia and lower 30-day mortality following pneumonia.
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