ArticleJournal of proteome research2012
Satiety hormone and metabolomic response to an intermittent high energy diet differs in rats consuming long-term diets high in protein or prebiotic fiber.
Article in Journal of proteome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Gut microbiota manipulation with prebiotics in patients with non-alcoholic fatty liver disease: a randomized controlled trial protocol.BMC gastroenterology · 2015Trial
- Postprandial effects of polydextrose on satiety hormone responses and subjective feelings of appetite in obese participants.Nutrition journal · 2015Trial
- Evaluation of yellow pea fibre supplementation on weight loss and the gut microbiota: a randomized controlled trial.BMC gastroenterology · 2014Trial
- Flavonoids fromJournal of enzyme inhibition and medicinal chemistry · 2026Article
- The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis.Frontiers in endocrinology · 2022Review
- Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review.Foods (Basel, Switzerland) · 2021Review
- The Microbiota and the Gut-Brain Axis in Controlling Food Intake and Energy Homeostasis.International journal of molecular sciences · 2021Review
- Polylactose Exhibits Prebiotic Activity and Reduces Adiposity and Nonalcoholic Fatty Liver Disease in Rats Fed a High-Fat Diet.The Journal of nutrition · 2021Article
- Gut microbiota and obesity: Impact of antibiotics and prebiotics and potential for musculoskeletal health.Journal of sport and health science · 2020Review
- Article
- Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats.European journal of nutrition · 2016Article
- Impact of Diet Composition in Adult Offspring is Dependent on Maternal Diet during Pregnancy and Lactation in Rats.Nutrients · 2016Article
- Independent and Combined Effects of Lactitol, Polydextrose, and Bacteroides thetaiotaomicron on Postprandial Metabolism and Body Weight in Rats Fed a High-Fat Diet.Frontiers in nutrition · 2016Article
- The role of short chain fatty acids in appetite regulation and energy homeostasis.International journal of obesity (2005) · 2015Review
- Metabolomic profiling in cattle experimentally infected with Mycobacterium avium subsp. paratuberculosis.PloS one · 2014Article
- Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Large differences in the composition of diet between early development and adulthood can have detrimental effects on obesity risk. We examined the effects of an intermittent high fat/sucrose diet (HFS) on satiety hormone and serum metabolite response in disparate diets. Wistar rat pups were fed control (C), high prebiotic fiber (HF) or high protein (HP) diets (weaning to 16 weeks), HFS diet challenged (6 weeks), and finally reverted to their respective C, HF, or HP diet (4 weeks). At conclusion, measurement of body composition and satiety hormones was accompanied by (1)H NMR metabolic profiles in fasted and postprandial states. Metabolomic profiling predicted dietary source with >90% accuracy. The HF group was characterized by lowest body weight and body fat (P<0.05) and increased satiety hormone levels (glucagon-like peptide 1 and peptide-YY). Regularized modeling confirmed that the HF diet is associated with higher gut hormone secretion that could reflect the known effects of prebiotics on gut microbiota and their fementative end products, the short chain fatty acids. Rats reared on a HF diet appear to experience fewer adverse effects from an intermittent high fat diet in adulthood when rematched to their postnatal diet. Metabolite profiles associated with the diets provide a distinct biochemical signature of their effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.