Trial reportInternational journal of dermatology2012
Efficacy of mesotherapy in facial rejuvenation: a histological and immunohistochemical evaluation.
Trial report in International journal of dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 80 citations in OpenAlex.
- Effects of Polyrevitalising Solution Injections Combined With Facelift Surgery on Facial Scar Healing and Skin Quality: A Split-Face Pilot Study.Aesthetic surgery journal. Open forum · 2026Article
- Safety and Efficacy of Mesotherapy with Placenta Polypeptide Injection for Moderate-to-Severe Sensitive Skin: A Multicenter, Randomized, Controlled Trial.Clinical, cosmetic and investigational dermatology · 2026Article
- Advanced on Minimally Invasive Techniques in Facial Rejuvenation: A Comprehensive Review.World journal of plastic surgery · 2026Review
- Assessment of Clients' Perceptions and Satisfaction With Eyebrow Mesotherapy Treatment.Journal of cosmetic dermatology · 2025Article
- Article
- Evaluating the Efficacy and Safety of Alpha-Hydroxy Acids in Dermatological Practice: A Comprehensive Clinical and Legal Review.Clinical, cosmetic and investigational dermatology · 2024Review
- Personalization of Minimally-Invasive Aesthetic Procedures with the Use of Ultrasound Compared to Alternative Imaging Modalities.Diagnostics (Basel, Switzerland) · 2023Review
- The Effectiveness of Injectable Hyaluronic Acid in the Improvement of the Facial Skin Quality: A Systematic Review.Clinical, cosmetic and investigational dermatology · 2023Review
- Clinical features of mesotherapy-associated non-tuberculous mycobacterial infections: A systematic review.International journal of women's dermatology · 2022Article
- A Novel Approach for Skin Regeneration by a Potent Bioactive Placental-Loaded Microneedle Patch: Comparative Study of Deer, Goat, and Porcine Placentas.Pharmaceutics · 2022Article
- Malar reshaping technique using bidirectional barb thread suspension procedure for 3-dimensional aging in Asian faces.International journal of women's dermatology · 2021Article
- A Call to Action by the Italian Mesotherapy Society on Scientific Research.Drug design, development and therapy · 2021Review
- Photoaging Skin Therapy with PRP and ADSC: A Comparative Study.Stem cells international · 2020Article
- In vitro study of RRS HA injectable mesotherapy/biorevitalization product on human skin fibroblasts and its clinical utilization.Clinical, cosmetic and investigational dermatology · 2016Article
- Polycomponent mesotherapy formulations for the treatment of skin aging and improvement of skin quality.Clinical, cosmetic and investigational dermatology · 2015Article
- Effects of dimethylaminoethanol and compound amino acid on D-galactose induced skin aging model of rat.TheScientificWorldJournal · 2014Article
- [Side effects in aesthetic medicine. Spectrum, management and avoidance].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMesotherapy, commonly known as "biorejuvenation" or "biorevitalization", is a technique used to rejuvenate the skin by means of a transdermal injection of a multivitamin solution and natural plant extracts that are thought to improve the signs of skin aging.
objectivesThis prospective study aimed to evaluate the clinical effect of mesotherapy applied to periorbital wrinkles and to quantitatively evaluate histological changes in the skin occurring in response to the same treatment.
methodsSix volunteers with Fitzpatrick skin types III or IV and Glogau class I-III wrinkles were subjected to a three-month course of mesotherapy injections in the periocular area (six sessions administered at two-week intervals). Standard photographs and skin biopsies were obtained from the treatment area at baseline, at the end of treatment, and at three months post-treatment. Quantitative evaluation of collagen types I, III, and VII, newly synthesized collagen, total elastin, and tropoelastin was performed using a computerized morphometric analysis.
resultsThe clinical evaluation of volunteers at baseline, end of treatment, and three months post-treatment revealed no significant differences. Histological and immunostaining analysis of collagen types I, III, and VII, newly synthesized collagen, total elastin, and tropoelastin showed no statistically significant changes (P > 0.05) after mesotherapy injection.
conclusionsThe present study indicates that mesotherapy for skin rejuvenation does not result in statistically significant histological changes or clinical improvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.