ArticleFrontiers in neural circuits2012
The origin of neocortical nitric oxide synthase-expressing inhibitory neurons.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 37 citations in OpenAlex.
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- Function and development of interneurons involved in brain tissue oxygen regulation.Frontiers in molecular neuroscience · 2022Review
- The Organization of Somatostatin-Immunoreactive Cells in the Visual Cortex of the Gerbil.Biomedicines · 2022Article
- Converging Effects of Three Different Endocrine Disrupters on Sox and Pou Gene Expression in Developing Rat Hippocampus: Possible Role of microRNA in Sex Differences.Frontiers in genetics · 2021Article
- Nitric oxide signalling in the brain and its control of bodily functions.British journal of pharmacology · 2020Review
- Npas1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Heterotopic Transplantations Reveal Environmental Influences on Interneuron Diversity and Maturation.Cell reports · 2017Article
- Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives.Biological psychiatry · 2017Review
- Binaural blood flow control by astrocytes: listening to synapses and the vasculature.The Journal of physiology · 2017Review
- Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons.Frontiers in cellular neuroscience · 2015Review
- Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex.Frontiers in neuroanatomy · 2015Article
- Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression.Neurobiology of disease · 2015Article
- The chandelier cell, form and function.Current opinion in neurobiology · 2014Review
- Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?Frontiers in pharmacology · 2013Review
- Biological substrates underpinning diagnosis of major depression.The international journal of neuropsychopharmacology · 2013Review
- Cortical NO interneurons: from embryogenesis to functions.Frontiers in neural circuits · 2013Review
- Beyond the frontiers of neuronal types.Frontiers in neural circuits · 2013Article
- Neuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits.Frontiers in neural circuits · 2012Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibitory neurons are critical for regulating effective transfer of sensory information and network stability. The precision of inhibitory function likely derives from the existence of a variety of interneuron subtypes. Their specification is largely dependent on the locale of origin of interneuron progenitors. Neocortical and hippocampal inhibitory neurons originate the subpallium, namely in the medial and caudal ganglionic eminences (MGE and CGE), and in the preoptic area (POA). In the hippocampus, neuronal nitric oxide synthase (nNOS)-expressing cells constitute a numerically large GABAergic interneuron population. On the contrary, nNOS-expressing inhibitory neurons constitute the smallest of the known neocortical GABAergic neuronal subtypes. The origins of most neocortical GABAergic neuron subtypes have been thoroughly investigated, however, very little is known about the origin of, or the genetic programs underlying the development of nNOS neurons. Here, we show that the vast majority of neocortical nNOS-expressing neurons arise from the MGE rather than the CGE. Regarding their molecular signature, virtually all neocortical nNOS neurons co-express the neuropeptides somatostatin (SST) and neuropeptide Y (NPY), and about half of them express the calcium-binding protein calretinin (CR). nNOS neurons thus constitute a small cohort of the MGE-derived SST-expressing population of cortical inhibitory neurons. Finally, we show that conditional removal of the transcription factor Sox6 in MGE-derived GABAergic cortical neurons results in an absence of SST and CR expression, as well as reduced expression of nNOS in neocortical nNOS neurons. Based on their respective abundance, origin and molecular signature, our results suggest that neocortical and hippocampal nNOS GABAergic neurons likely subserve different functions and have very different physiological relevance in these two cortical structures.
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