ArticleInternational journal of nanomedicine2012
Protein encapsulation in polymeric microneedles by photolithography.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Highly cited original research in microneedle science from 2015 to 2025 a bibliometric and altmetric analysis.Discover nano · 2026Review
- Prediction of drug permeation through microneedled skin by machine learning.Bioengineering & translational medicine · 2023Article
- Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals.Pharmaceutics · 2023Review
- Microneedle mediated transdermal delivery of β-sitosterol loaded nanostructured lipid nanoparticles for androgenic alopecia.Drug delivery · 2022Article
- Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications.Pharmaceutics · 2022Review
- 3D printing of pharmaceuticals: approach from bench scale to commercial development.Future journal of pharmaceutical sciences · 2022Review
- Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection.Molecular pharmaceutics · 2020Article
- Progress in Microneedle-Mediated Protein Delivery.Journal of clinical medicine · 2020Review
- Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion.Bioengineering (Basel, Switzerland) · 2018Article
- 3D-Printing of Functional Biomedical Microdevices via Light- and Extrusion-Based Approaches.Small methods · 2018Article
- Dissolving Microneedle Patches for Dermal Vaccination.Pharmaceutical research · 2017Review
- Personalised 3D Printed Medicines: Which Techniques and Polymers Are More Successful?Bioengineering (Basel, Switzerland) · 2017Review
- Large Size Microneedle Patch to Deliver Lidocaine through Skin.Pharmaceutical research · 2016Article
- Single-Step Fabrication of Computationally Designed Microneedles by Continuous Liquid Interface Production.PloS one · 2016Article
- Polymeric Microneedle Array Fabrication by Photolithography.Journal of visualized experiments : JoVE · 2015Article
- Delivery of large molecular protein using flat and short microneedles prepared using focused ion beam (FIB) as a skin ablation tool.Drug delivery and translational research · 2015Article
- Direct microneedle array fabrication off a photomask to deliver collagen through skin.Pharmaceutical research · 2014Article
- Clear castable polyurethane elastomer for fabrication of microfluidic devices.Lab on a chip · 2013Article
- Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects.Dose-response : a publication of International Hormesis SocietyReview
- Modeling Polymeric Drug Release: The Emerging Role of Machine Learning.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent interest in biocompatible polymeric microneedles for the delivery of biomolecules has propelled considerable interest in fabrication of microneedles. It is important that the fabrication process is feasible for drug encapsulation and compatible with the stability of the drug in question. Moreover, drug encapsulation may offer the advantage of higher drug loading compared with other technologies, such as drug coating. METHODS AND
resultsIn this study, we encapsulated a model protein drug, namely, bovine serum albumin, in polymeric microneedles by photolithography. Drug distribution within the microneedle array was found to be uniform. The encapsulated protein retained its primary, secondary, and tertiary structural characteristics. In vitro release of the encapsulated protein showed that almost all of the drug was released into phosphate buffered saline within 6 hours. The in vitro permeation profile of encapsulated bovine serum albumin through rat skin was also tested and shown to resemble the in vitro release profile, with an initial release burst followed by a slow release phase. The cytotoxicity of the microneedles without bovine serum albumin was tested in three different cell lines. High cell viabilities were observed, demonstrating the innocuous nature of the microneedles.
conclusionThe microneedle array can potentially serve as a useful drug carrier for proteins, peptides, and vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.