ArticleJournal of emergencies, trauma, and shock2012
Correlation of C-reactive protein to severity of symptoms in acute influenza A infection.
Article in Journal of emergencies, trauma, and shock, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Does C-reactive protein predict time to recovery and benefit from oseltamivir treatment in primary care patients with influenza-like illness? A randomized controlled trial secondary analysis.Scandinavian journal of primary health care · 2021Trial
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- Comparative analysis of CRP as a biomarker of the inflammatory response intensity among common viral infections affecting the lungs: COVID-19 versus influenza A, influenza B and respiratory syncytial virus.Clinical and experimental medicine · 2023Article
- Model-informed precision dosing in vancomycin treatment.Frontiers in pharmacology · 2023Article
- A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus macaque (Macaca mulatta) model.PLoS neglected tropical diseases · 2022Article
- Healthcare-associated infection after spinal cord injury in a tertiary rehabilitation center in South Korea: a retrospective chart audit.Spinal cord · 2021Observational
- Influenza infection, SARS, MERS and COVID-19: Cytokine storm - The common denominator and the lessons to be learned.Clinical immunology (Orlando, Fla.) · 2021Review
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- How to Synchronize Longitudinal Patient Data With the Underlying Disease Progression: A Pilot Study Using the Biomarker CRP for Timing COVID-19.Frontiers in medicine · 2021Article
- Pattern Recognition Proteins: First Line of Defense Against Coronaviruses.Frontiers in immunology · 2021Review
- Is C-reactive protein associated with influenza A or B in primary care patients with influenza-like illness? A cross-sectional study.Scandinavian journal of primary health care · 2020Article
- Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability.Animals : an open access journal from MDPI · 2020Article
- Acute phase protein response to viral infection and vaccination.Archives of biochemistry and biophysics · 2019Review
- Salivary C-reactive protein among at-risk adolescents: A methods investigation of out of range immunoassay data.Psychoneuroendocrinology · 2019Article
- Admission inflammatory markers and isolation of a causative organism in patients with spontaneous spinal infection.Annals of the Royal College of Surgeons of England · 2013Article
- Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently there is no objective measure to determine disease severity in patients with acute influenza infection. During acute viral infections, C-reactive protein (CRP) has been shown to be elevated.
aimTo study the relationship between the symptoms of acute influenza A infection and correlate them with the level of inflammation as measured by serum CRP levels. SETTINGS AND
designProspective study. MATERIALS AND
methodsWe enrolled a convenience sample of adults presenting to an urban academic emergency department (ED), who had positive Enzyme-linked immunosorbent assay detection of the influenza A antigen. The subjects were excluded if they had immunosuppression, liver disease or were currently taking antiviral medication. A previously validated severity of symptom (SOS) score was calculated by asking the participants to record the severity of seven symptoms associated with influenza infection. The subjects had the serum C-reactive protein (CRP) levels tested during their ED visit. STATISTICAL ANALYSIS: A linear regression model was used with CRP as a predictor of the SOS score. Pearson's product-moment coefficient was used to measure the dependence between the two quantities.
resultsThirty-two subjects were enrolled from January through March 2009, and of those, eight patients were excluded from the analysis, leaving 24 study subjects: 58% were women, of ages 18 to 63 years, with a mean age of 31 years (95% CI 25, 37). The mean SOS score was 14.1 ranging from 6 to 21 (95% CI 12.6, 26.4). The mean CRP score was 24.6 ranging from 0 to 64.7 (95% CI 15.8, 33.4). The correlation coefficient between the SOS score and CRP levels was r = 0.65 (P=0.00056).
conclusionThe severity of symptoms associated with acute influenza A infection correlateswith the serum CRP levels.
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