ArticleJournal of virology2012
A multivalent adsorption apparatus explains the broad host range of phage phi92: a comprehensive genomic and structural analysis.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Phylogeny-agnostic strain-level prediction of phage-host interactions from genomes using machine learning.Nature microbiology · 2026Article
- Phage host range: determinants, dynamics and applications.Nature reviews. Microbiology · 2026Review
- Intact architectures of myophage phi92 in extended and contracted states.PLoS pathogens · 2026Article
- Novel Escherichia coli phages representing a distinct genus within the subfamily Stephanstirmvirinae: genome and host range characteristics.Archives of virology · 2025Article
- Dual-Receptor Recognition, Lysis Inhibition, Endolysin Release, and Reaction-Diffusion as Alternative Explanations. Comment on Rojero et al. Bypassing Evolution of Bacterial Resistance to Phages: The Example of Hyper-Aggressive Phage 0524phi7-1.International journal of molecular sciences · 2025Article
- Determination of bacteriophage ETEC-phage-TG to control pathogenic Escherichia coli.BMC research notes · 2025Article
- Isolation and Characterization of Four New Coliphages against Extra Intestinal PathogenicACS omega · 2025Article
- Review
- Two receptor-targeting mechanisms of lambda-like siphophage Gifsy-1 of Salmonella Typhimurium.PLoS pathogens · 2025Article
- Physicochemical, genomic, and phenotypic characterization ofMicrobiology spectrum · 2025Article
- Two novel polyvalent phages: a promising approach for cross-order pathogen control in aquaculture.Virology journal · 2025Article
- Complete genome sequence ofMicrobiology resource announcements · 2025Article
- Completing the BASEL phage collection to unlock hidden diversity for systematic exploration of phage-host interactions.PLoS biology · 2025Article
- Bacteriophage cocktail LEC2-LEC10 for broad-spectrum control of pathogenic and uncharacterizedFrontiers in microbiology · 2025Article
- A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections.Nature communications · 2024Article
- The branched receptor-binding complex ofiScience · 2024Article
- Deciphering the adsorption machinery of Deep-Blue and Vp4, two myophages targeting members of theJournal of virology · 2024Article
- Characterization of bacteriophages infecting multidrug-resistant uropathogenic Escherichia coli strains.Archives of virology · 2024Article
- Prediction of Klebsiella phage-host specificity at the strain level.Nature communications · 2024Article
- Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophage phi92 is a large, lytic myovirus isolated in 1983 from pathogenic Escherichia coli strains that carry a polysialic acid capsule. Here we report the genome organization of phi92, the cryoelectron microscopy reconstruction of its virion, and the reinvestigation of its host specificity. The genome consists of a linear, double-stranded 148,612-bp DNA sequence containing 248 potential open reading frames and 11 putative tRNA genes. Orthologs were found for 130 of the predicted proteins. Most of the virion proteins showed significant sequence similarities to proteins of myoviruses rv5 and PVP-SE1, indicating that phi92 is a new member of the novel genus of rv5-like phages. Reinvestigation of phi92 host specificity showed that the host range is not limited to polysialic acid-encapsulated Escherichia coli but includes most laboratory strains of Escherichia coli and many Salmonella strains. Structure analysis of the phi92 virion demonstrated the presence of four different types of tail fibers and/or tailspikes, which enable the phage to use attachment sites on encapsulated and nonencapsulated bacteria. With this report, we provide the first detailed description of a multivalent, multispecies phage armed with a host cell adsorption apparatus resembling a nanosized Swiss army knife. The genome, structure, and, in particular, the organization of the baseplate of phi92 demonstrate how a bacteriophage can evolve into a multi-pathogen-killing agent.
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