Evidence map›Paper›PMID 22787223›Full record

ArticleJournal of virology2012

Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo.

Katja Mueller, Anne von Mässenhausen, Ulrike Aichele, Lilian Stärck, Matthias Leisegang, Wolfgang Uckert, Hanspeter Pircher

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Updates on Chronic HBV: Current Challenges and Future Goals.Current treatment options in gastroenterology · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Katja MuellerInstitute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany.
Anne von Mässenhausen
Ulrike Aichele
Lilian Stärck
Matthias Leisegang
Wolfgang Uckert
Hanspeter Pircher
Max Delbrück Center · DEInstitute of Medical Microbiology and Hygiene · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.

Indexed as

AnimalsAntigensAntigens, ViralCD8-Positive T-LymphocytesCell MembraneCytokinesFlow CytometryGlycoproteinsInterferon-gammaListeria monocytogenesLymphocytesLymphocytic choriomeningitis virusMicePeptide FragmentsPhenotypeReceptors, Antigen, T-CellAntigensAntigens, ViralCytokinesglycoprotein peptide 33-41, Lymphocytic choriomeningitis virusGlycoproteinsInterferon-gammaPeptide FragmentsReceptors, Antigen, T-CellViral Proteins

Identifiers

PMID22787223
PMCPMC3457306
OpenAlexW2120435002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.