ArticleClinical and vaccine immunology : CVI2012
Memory CD8+ T cells are sufficient to alleviate impaired host resistance to influenza A virus infection caused by neonatal oxygen supplementation.
Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Variances in Antiviral Memory T-Cell Repertoire of CD45RA- and CD62L-Depleted Lymphocyte Products Reflect the Need of Individual T-Cell Selection Strategies to Reduce the Risk of GvHD while Preserving Antiviral Immunity in Adoptive T-Cell Therapy.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2022Article
- Low-dose hyperoxia primes airways for fibrosis in mice after influenza A infection.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- DNA Methylation Patterns inEnvironmental health perspectives · 2021Article
- Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice.Scientific reports · 2020Article
- Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice.bioRxiv : the preprint server for biology · 2020Article
- Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses.The Journal of allergy and clinical immunology · 2018Article
- Oxygen-dependent changes in lung development do not affect epithelial infection with influenza A virus.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Affect of Early Life Oxygen Exposure on Proper Lung Development and Response to Respiratory Viral Infections.Frontiers in medicine · 2015Review
- Neonatal hyperoxia leads to persistent alterations in NK responses to influenza A virus infection.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Neonatal hyperoxia stimulates the expansion of alveolar epithelial type II cells.American journal of respiratory cell and molecular biology · 2014Article
- Neonatal oxygen exposure alters airway hyper-responsiveness but not the response to allergen challenge in adult mice.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2014Article
- Neonatal hyperoxia alters the host response to influenza A virus infection in adult mice through multiple pathways.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Neonatal hyperoxia increases sensitivity of adult mice to bleomycin-induced lung fibrosis.American journal of respiratory cell and molecular biology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Supplemental oxygen administered to preterm infants is an important clinical intervention, but it is associated with life-long changes in lung development and increased sensitivity to respiratory viral infections. The precise immunological changes caused by neonatal oxygen treatment remain poorly understood. We previously reported that adult mice exposed to supplemental oxygen as neonates display persistent pulmonary inflammation and enhanced mortality after a sublethal influenza A virus infection. These changes suggest that neonatal hyperoxia impairs the cytotoxic CD8(+) T cell response required to clear the virus. In this study, we show that although host resistance to several different strains of influenza A virus is reduced by neonatal hyperoxia, this treatment does not impair viral clearance, nor does it alter the magnitude of the virus-specific CD8(+) T cell response to primary infection. Moreover, memory T cells are sufficient to ameliorate the increased morbidity and mortality and alleviate the excessive lung damage observed in mice exposed to high oxygen levels as neonates, and we attribute this sufficiency principally to virus-specific memory CD8(+) T cells. Thus, we show that neonatal hyperoxia reduces host resistance to influenza virus infection without diminishing the function of cytotoxic T lymphocytes or the generation of virus-specific memory T cells and that CD8(+) memory T cells are sufficient to provide protection from negative consequences of this important life-saving intervention. Our findings suggest that vaccines that generate robust T cell memory may be efficacious at reducing the increased sensitivity to respiratory viral infections in people born prematurely.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.