ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Rapid homeostatic plasticity of intrinsic excitability in a central pattern generator network stabilizes functional neural network output.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A bibliometric analysis of synaptic plasticity and epilepsy from 2003 to 2023.Frontiers in neurology · 2025Pooled it
- When can neuronal activity-dependent homeostatic plasticity maintain circuit-level properties?Journal of computational neuroscience · 2026Article
- Conductance relationships across compartments associated with bursting output in a model of a motor neuron in the crustacean cardiac ganglion.Journal of neurophysiology · 2026Article
- Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing.Current biology : CB · 2025Article
- Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures.BMC biology · 2024Article
- Article
- Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures.bioRxiv : the preprint server for biology · 2024Article
- A biophysical perspective on the resilience of neuronal excitability across timescales.Nature reviews. Neuroscience · 2023Review
- Molecular profiling of COComparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2023Article
- Motor neurons within a network use cell-type specific feedback mechanisms to constrain relationships among ion channel mRNAs.Journal of neurophysiology · 2023Article
- Gating of homeostatic regulation of intrinsic excitability produces cryptic long-term storage of prior perturbations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Oscillatory network spontaneously recovers both activity and robustness after prolonged removal of neuromodulators.Frontiers in cellular neuroscience · 2023Article
- Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate.PLoS biology · 2023Article
- Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium.Frontiers in cellular neuroscience · 2023Article
- Dynamics of ramping bursts in a respiratory neuron model.Journal of computational neuroscience · 2022Article
- Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome.Cell reports · 2020Article
- Rapid adaptation to elevated extracellular potassium in the pyloric circuit of the crab,Journal of neurophysiology · 2020Article
- The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response.PLoS genetics · 2019Article
- Article
- Combined mechanisms of neural firing rate homeostasis.Biological cybernetics · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons and networks undergo a process of homeostatic plasticity that stabilizes output by integrating activity levels with network and cellular properties to counter longer-term perturbations. Here we describe a rapid compensatory interaction among a pair of potassium currents, I(A) and I(KCa), that stabilizes both intrinsic excitability and network function in the cardiac ganglion of the crab, Cancer borealis. We determined that mRNA levels in single identified neurons for the channels which encode I(A) and I(KCa) are positively correlated, yet the ionic currents themselves are negatively correlated, across a population of motor neurons. We then determined that these currents are functionally coupled; decreasing levels of either current within a neuron causes a rapid increase in the other. This functional interdependence results in homeostatic stabilization of both the individual neuronal and the network output. Furthermore, these compensatory increases are mechanistically independent, suggesting robustness in the maintenance of neural network output that is critical for survival. Together, we generate a complete model for homeostatic plasticity from mRNA to network output where rapid post-translational compensatory mechanisms acting on a reservoir of channels proteins regulated at the level of gene expression provide homeostatic stabilization of both cellular and network activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.