ArticleJournal of neurophysiology2012
Phase response curves of subthalamic neurons measured with synaptic input and current injection.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Model-based design of subthalamic nucleus neurons using hybrid optimization.Journal of neurophysiology · 2026Article
- The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability.Biological cybernetics · 2022Review
- Evidence of two modes of spiking evoked in human firing motoneurones by Ia afferent electrical stimulation.Experimental brain research · 2021Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- How to correctly quantify neuronal phase-response curves from noisy recordings.Journal of computational neuroscience · 2019Article
- Population dynamics and entrainment of basal ganglia pacemakers are shaped by their dendritic arbors.PLoS computational biology · 2019Article
- Beta-Band Resonance and Intrinsic Oscillations in a Biophysically Detailed Model of the Subthalamic Nucleus-Globus Pallidus Network.Frontiers in computational neuroscience · 2019Article
- Phase-locking and bistability in neuronal networks with synaptic depression.Physica D. Nonlinear phenomena · 2018Article
- Dopaminergic modulation of basal ganglia output through coupled excitation-inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Driving reservoir models with oscillations: a solution to the extreme structural sensitivity of chaotic networks.Journal of computational neuroscience · 2016Article
- Phasic Burst Stimulation: A Closed-Loop Approach to Tuning Deep Brain Stimulation Parameters for Parkinson's Disease.PLoS computational biology · 2016Article
- Phase-resetting as a tool of information transmission.Current opinion in neurobiology · 2015Review
- Predicting the responses of repetitively firing neurons to current noise.PLoS computational biology · 2014Article
- Spectral reconstruction of phase response curves reveals the synchronization properties of mouse globus pallidus neurons.Journal of neurophysiology · 2013Article
- Active decorrelation in the basal ganglia.Neuroscience · 2013Review
- Hippocampal CA1 pyramidal neurons exhibit type 1 phase-response curves and type 1 excitability.Journal of neurophysiology · 2013Article
- Optimal number of stimulation contacts for coordinated reset neuromodulation.Frontiers in neuroengineering · 2013Article
- Desynchronization boost by non-uniform coordinated reset stimulation in ensembles of pulse-coupled neurons.Frontiers in computational neuroscience · 2013Article
- Biophysical basis of the phase response curve of subthalamic neurons with generalization to other cell types.Journal of neurophysiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Infinitesimal phase response curves (iPRCs) provide a simple description of the response of repetitively firing neurons and may be used to predict responses to any pattern of synaptic input. Their simplicity makes them useful for understanding the dynamics of neurons when certain conditions are met. For example, the sizes of evoked phase shifts should scale linearly with stimulus strength, and the form of the iPRC should remain relatively constant as firing rate varies. We measured the PRCs of rat subthalamic neurons in brain slices using corticosubthalamic excitatory postsynaptic potentials (EPSPs; mediated by both AMPA- and NMDA-type receptors) and injected current pulses and used them to calculate the iPRC. These were relatively insensitive to both the size of the stimulus and the cell's firing rate, suggesting that the iPRC can predict the response of subthalamic nucleus cells to extrinsic inputs. However, the iPRC calculated using EPSPs differed from that obtained using current pulses. EPSPs (normalized for charge) were much more effective at altering the phase of subthalamic neurons than current pulses. The difference was not attributable to the extended time course of NMDA receptor-mediated currents, being unaffected by blockade of NMDA receptors. The iPRC provides a good description of subthalamic neurons' response to input, but iPRCs are best estimated using synaptic inputs rather than somatic current injection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.